| ObjectiveThe purpose of this study is to observe the curative effect of "Tongjiaolimian" acupoint application in the treatment of chronic insomnia,and to notarize the effectiveness of "Tongjiaolimian" acupoint application in the treatment of chronic insomnia.Methods60 eligible patients with chronic insomnia were collected.All patients were divided into the acupoint application group(treatment group)and medicine group(control group)randomly according to a 1:1 ratio after signing the informed consent form.Tongjiaolimian application were sticked at acupoints which named Jiuwei and Shenque in the application group;the medicine group was given Estezolam tablet 10mg/qn,30 min before sleeping.1 week as a course of treatment,treating the two groups for4 courses.PSQI scores and AIS scores were recorded before treatment,at the end of second course,at the end of fourth course of treatment and follow-up for statistical analysis.The total effective rate at the end of the fourth course and the follow-up was evaluated respectively.Adverse events occurred during treatment were recorded in detai.Results(1)PSQI scale scores:(1)intra-group comparison: The total score of PSQI in both groups was improved after treatment(P<0.001).The scores of PSQI in application group were improved at each time-point after treatment(P<0.05);The scores of PSQI in the second and fourth courses of treatment were improved in the medicine group(P<0.05).At follow-up,the sleep quality was similar to that before treatment(P>0.05).(2)Comparison between groups: The efficacy of the medicine group in the second course was better than that of the application group(P<0.001);At the 4th course the two groups has the similar effects(P<0.05).The treatment effect of application group was better than that of medicine group at follow-up(P<0.05).PSQI scores: the treatment effect of the two groups was similar,and the maintenance effect of the application group was better than that of the medicine group(P<0.05).(2)AIS scale score:(1)intra-group comparison: Compared with before-treatment,the AIS score of the two groups were declined at all time-points after treatment(P<0.001).(2)Comparison between groups: the treatment effect of the medicine group was better than application group at the end of second course(P<0.001);the treatment effect of the two groups was similar at the end of fourth course(P>0.05);the treatment effect of the application group was better than that of the medicine group at follow-up time(P<0.001).(3)The total effective rate: After 4 courses of treatment,the total effective rate of the two groups was similar(P>0.05);The long-term efficacy of application group was better than that of medicine group(P<0.05).Conclusion(1)The "Tongjiaolimian paste" acupoint application has a reliable effect in treating chronic insomnia.(2)The effect rate of the "Tongjiaolimien paste" acupoint application is slower than that of oral esazolam,and the two treatments have the same effect after 4courses of treatment.And the maintenance effect of "Tongjiaolimian paste" on the treatment effect was better than that of estazolam.(3)The adverse reaction of "Tongjiaolimian paste" were less than those of estazolam tablet. |
