Study On The Correlation Between FeNO Levels And TCM Syndromes Of Chronic Cough And Observation Of Curative Effect Of Qufeng Kemin Fang

Objective1.Compare the differences in general information,syndrome manifestations,TCM syndrome types,and blood eosinophil distribution in chronic cough patients with different FeNO levels,and explore the correlation between FeNO levels and TCM syndromes of chronic cough.2.Through a clinical randomized controlled trial to observe and analyze the curative effect of Professor Sun Zengtao’s Experienced Formula Qufeng Kemin Prescription in the treatment of cough variant asthma,and clarify its advantages in the treatment of cough variant asthma.Methods1.The study cases included 132 patients with chronic cough who met the inclusion criteria in the Respiratory Department of the Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine from November 2019 to February 2021.According to the FeNO level,all cases were divided into FeNO normal group and FeNO elevated group,of which 61 cases were FeNO normal group and 71 were FeNO elevated group.Use the clinical syndrome questionnaire to record the two groups of patients,record the relevant auxiliary examinations,and use SPSS 22.0 for statistical analysis.2.Using a clinical randomized controlled trial design,64 patients with cough variant asthma who met the inclusion criteria who were admitted to the outpatient clinic from November 2019 to February 2021 were treated in groups,32 cases each in the traditional Chinese medicine group and the western medicine group,and the two groups were treated with continuous medication for 2 weeks.The cough VAS score,TCM syndrome score,and Leicester quality of life score for cough before and after treatment were compared between the two groups of patients,and SPSS 22.0 was used for statistical analysis.Results1.Among the 132 patients with chronic cough included in the first part of the study,female patients are more common.Among the clinical symptoms,the frequency of nocturnal cough,paroxysmal cough,low sputum volume,dry cough without sputum,foamy sputum,transparent sputum color,irritation of peculiar smell,and pharyngeal itching symptoms showed a significant upward trend with the increase of FeNO levels.On the distribution of syndromes,"Feng Xie Fu Fei","Fei Pi Liang Xu" and "Tan Re Yu Fei" are the common syndromes.The FeNO value of “Feng Xie Fu Fei” Syndrome is significantly higher than that of other syndrome types,and the proportion in the distribution of syndrome types has a certain upward trend with the increase of FeNO level.The percentage of blood eosinophils in the two groups was positively correlated with FeNO levels.2.The results of Qufeng Kemin Decoction in the treatment of cough variant asthma with wind-evil and lung syndrome showed that in terms of cough VAS score,the comparison between the two groups of patients before and after treatment,the traditional Chinese medicine group Z=-4.916,P=0.00(<0.01),Western medicine Group Z=-1.528,P=0.127(<0.05),there are statistical differences.The comparison between the two groups was Z=-0.587,P=0.558(>0.05),which was not statistically significant.In terms of improving each single symptom,the two groups of treatments improved the symptoms of daytime cough,night cough,phlegm,dry throat,itchy throat,induced or worsened by irritants,shortness of breath and chest tightness(P<0.05).The comparison between the groups showed that there was a statistical difference between the two groups in terms of improving daytime cough,dry throat,itchy throat,induced or worsened by irritants,shortness of breath and chest tightness(P<0.05),and improved night cough and sputum symptoms On the one hand,there was no statistical difference between the two groups(P>0.05).In terms of TCM syndrome scores,the comparison between the two groups,the traditional Chinese medicine group Z=-4.953,P=0.00(<0.01),the western medicine group Z=-4.891,P=0.00(<0.01),there are statistical differences between the two groups.Comparison between groups,Z=-3.743,P=0.00(<0.01),there is a statistical difference.In terms of quality of life,according to the Leicester Cough Questionnaire score,the two treatments improved in the psychological,physical,social and total scores of cough quality of life(P<0.05).The comparison between the two groups showed that the two groups were in cough quality of life.There were no statistically significant differences in psychological,physical,social and total scores(P<0.05).In terms of total effective rate,in the traditional Chinese medicine group,1 case was clinically controlled(3.13%),9 cases were markedly effective(28.13%),21 cases were effective(65.63%),and 1 case was ineffective(3.13%).The total effective rate was 96.88%;the western medicine group 0 cases were clinically controlled,2 cases were markedly effective(6.25%),28 cases were effective(87.5%),and 2 cases were ineffective(6.25%).The total effective rate was 93.75%.The effective rate of the two groups was compared X2=6.717,P=0.046,there were statistical differences between the two groups.Conclusion1.The first part of the study shows that chronic cough patients are more common in women.With the increase of FeNO levels,the frequency of night cough,coughing,low sputum volume,dry cough without sputum,foamy sputum,transparent sputum color,irritation of peculiar smell,and itchy throat symptoms have increaseed significantly.The most common types of chronic cough are "Feng Xie Fu Fei","Fei Pi Liang Xu" and "Tan Re Yu Fei".Among them,the syndrome of "Feng Xie Fu Fei" is closely related to the increase of FeNO value.There was no statistical difference in pulmonary function indexes between the two groups,indicating that exhaled nitric oxide is more sensitive than pulmonary function and can reflect the characteristics of TCM syndromes in patients with chronic cough.The percentage of blood eosinophils and FeNO levels can complement each other in reflecting airway inflammation and clinical characteristics.2.The second part of the research shows that Qufeng Kemin Decoction can significantly improve patients’ cough symptoms,accompanying symptoms,TCM syndromes and quality of life in the treatment of cough variant asthma with wind-evil syndrome,and it has high safety and no obvious side effects.It is worthy of further promotion in the clinic.