| Objective: To explore the application value of contrast-enhanced ultrasound(CEUS)and quantitative parameters of contrast-enhanced ultrasound in children with retroperitoneal tumors,and to provide more accurate imaging methods for early clinical diagnosis and differential diagnosis of children with retroperitoneal tumors.Methods: A total of 39 children with retroperitoneal tumors were collected from August 2019 to April 2021 in the Department of Urology and Oncology,Children’s Hospital of Chongqing Medical University.All of them were pathologically confirmed,including neuroblastoma(Neuroblastoma,NB).)24 cases,10 cases of Wilms’ tumor(WT),and 5cases of Ganglion Cell Neuroblastoma(GNB).Analyze the features of conventional ultrasound and contrast-enhanced ultrasound images of all cases,and use Sono Liver software’s dynamic vascular pattern(Dynamic vascular pattern,DVP)technology and output time-intensity curve processing technology,offline analysis to obtain DVP curve and time intensity data.Results: 1.The three groups of neuroblastoma,Wilms tumor,and ganglion cell neuroblastoma had differences in the distribution of laboratory indicators of neuroenolase and vanilla mandelic acid in urine,and the differences were statistically significant(P< 0.05).2.Conventional ultrasound shows that most of neuroblastomas are moderately hypoechoic and obvious calcification,while Wilms tumors are mainly moderately echoic with a small amount of calcification,and ganglion cell neuroblastomas are mainly hypoechoic and obvious calcification..The differences in internal echo and calcification distribution of the three types of tumors were statistically significant(P<0.05).3.The contrast-enhanced ultrasound results showed that the imaging time of contrast agent in Wilms tumor was earlier than that in neuroblastoma,and the difference was statistically significant(P<0.05),while the imaging time of contrast agent in neuroblastoma and ganglion cell neuroblastoma The difference was not statistically significant.In the imaging mode,most of neuroblastoma and Wilms tumor are characterized by high enhancement,unevenness,and fast forward,while ganglion cell neuroblastoma is mostly characterized by low enhancement,uneven,and fast forward.The differences in the imaging time,contrast enhancement level and contrast mode of the intratumoral contrast agent in the three groups of cases were statistically significant(P<0.05).4.Taking the normal liver parenchyma or renal cortex as the reference zone,the quantitative parameter results of angiography of the three groups of cases showed that the rising time(Rising Time,RT)of neuroblastoma and Wilms tumor was earlier than the reference zone(P<0.05),and Ganglion cell neuroblastoma is slightly later than the reference area.5.The incidence of adverse reactions during the contrast-enhanced ultrasound in this group was 3.05%.Conclusion: 1.Neural enolase and vanilla mandelic acid in urine are the main tumor markers for distinguishing neuroblastoma from Wilms’ tumor.2.The calcification in neurogenic tumors is obvious in conventional ultrasound,which is one of the important points of distinguishing from the ultrasound image of Wilms tumor.3.Neuroblastoma,Wilms tumor,and ganglion cell neuroblastoma contrast-enhanced ultrasound imaging time,the enhancement level of contrast-enhanced ultrasound and the contrast mode difference in the tumor can provide more imaging information for the differential diagnosis of the three,To provide new imaging methods for the clinical diagnosis and differential diagnosis of the above three tumors.4.The rise time in the contrast-enhanced ultrasound time-intensity data quantitatively analyzes the contrast results,which is expected to become an effective parameter for the differential diagnosis of the three groups of cases.5.The application of contrast-enhanced ultrasound in children with retroperitoneal tumors has a certain safety effect. |
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