The Value Of Peripheral Blood Neutrophil/Lymphocyte Ratio And Platelet/Lymphocyte Ratio In Diagnosis Of Prostate Cancer

Objective: The clinical data of 179 patients undergoing prostate puncture were analyzed to explore the value of peripheral blood neutrophil-lymphocyte ratio(NLR)and platelet/lymphocyte ratio(PLR)in the diagnosis of prostate cancer(PCA),so as to obtain a biochemical index that can effectively predict the occurrence and progression of PCA disease.Methods: A total of 179 patients who underwent prostate biopsy in the Third Hospital of Hebei Medical University from January 2010 to September2020 were selected.According to pathological results,the patients were divided into PCa group(n = 88)and BPH group(n = 91).Collected the clinical data of two groups of patients before piercing,including patient age,routine blood test results(including neutrophil count,lymphocyte count and platelet count),total serum PSA(PSA),pathological results,Gleason score,MRI,ultrasound and whole-body nuclide bone scan results.Clinical staging was performed according to TNM staging criteria for prostate cancer,and NLR and PLR values were calculated from the results of blood routine.Statistical methods were used to analyze and evaluate the predictive diagnostic value of related indicators in the screening and progression of prostate cancer patients.Results: 1.Age(P < 0.001),PSA(P < 0.001)and lymphocyte count(P=0.018)were statistically significant between the two groups.Patients in the PCa group had higher age and PSA value but lower lymphocyte count.2.NLR value of PCa patients was significantly higher than that of BPH patients,2.76(2.03,4.00)VS 2.40(1.63,3.32),(P=0.011);The PLR value of PCa patients was significantly higher than that of BPH patients(144.98(107.32,191.35)VS 132.12(96.77,177.29),P=0.043).According to ROC curve,the optimal NLR and PLR cutoff values determined by Youden index were 2.90 and236.65.The sensitivity and specificity of combined diagnostic indicator including NLR,PLR and PSA were 70.5% and 92.3%.3.The sensitivity and specificity of PLR for bone metastasis were 62.5% and 97.0%.The sensitivity and specificity of NLR for clinical staging were 57.6% and 74.5%.The sensitivity and specificity of PLR for Gleason score were 79.7% and 62.5%.Conclusions:1.Peripheral blood NLR and PLR play a role in the diagnosis of prostate cancer.2.NLR and PLR are less effective than PSA in diagnosis alone.Combining NLR,PLR,and PSA can clinically identify more prostate cancer patients.3.NLR and PLR play a role in the diagnosis of prostate cancer progression.