Clinical Observation On Treatment Of Peri-Menopausal Insomnia Of Yin Deficiency And Fire Flourishing Type By Pang’s Gengnian An Decoction Modified Prescriptions

Objective:By observing the clinical effect of Pang’s Gengnian An decoction modified prescriptions and Kuntai capsule on peri-menopausal insomnia of Yin deficiency and Fire flourishing type,the effects of Pang’s Gengnian An decoction modified prescriptions on sleep quality,TCM syndrome score and serum sex hormone were evaluated objectively,which provided the basis for the further formation of safe and effective diagnosis and treatment methods.Method:Sixty cases of insomnia were randomly divided into treatment group and control group.The treatment group was treated with Pang’s Gengnian An decoction modified prescriptions and the control group with Kuntai capsule for 4 weeks.The changes of TCM syndrome scale score,Pittsburgh Sleep quality Index（PSQI）scale score,domestic modified Kupperman（KMI）scale score and serum sex hormone level were observed after treatment,and the observed data were statistically analyzed.Result:1.Analysis of comprehensive curative effect on insomnia after treatment:The total effective rate of Pang’s Gengnian An decoction modified prescriptions in the treatment group was 96.43%,while that in the control group was 81.48%.There was a significant difference in the comprehensive effect of insomnia between the two groups（P<0.05）,and the improvement effect in the treatment group was more obvious.Compared with the scores of PSQI scale and total score,there were significant differences in falling asleep time,sleep efficiency,daytime dysfunction and total score of PSQI between the two groups,and the treatment group was significantly better than the control group in sleep quality,sleep time and sleep disorders（P<0.05）,and the treatment group was superior to the control group in sleep quality,sleep time and sleep disorder.2.Comparison of Therapeutic effects of TCM Syndromes after treatment:The effective rate of TCM syndrome was 96.43%in the treatment group and 81.48%in the control group.There was a significant difference in the curative effect of TCM syndrome between the two groups after treatment（P<0.05）.According to the comparison of the items and total scores of TCM syndromes,there were significant differences in the improvement of five upset heat,irritability and total scores of TCM syndromes between the two groups（P<0.05）.The curative effect of Pang’s Gengnian An decoction modified prescriptions was better.There were significant differences between the two groups in the improvement of difficulty in falling asleep,difficulty in continuous sleep,hot night sweats,sore waist and knees,hot sweating,dizziness and tinnitus,dry mouth,dry eyes and short red urine（P<0.05）.The treatment group was better than the control group in terms of constipation.There was no significant difference in the curative effect of constipation between the two groups（P>0.05）.3.Analysis of modified KMI scale after treatment:There was a significant difference in KMI score between the two groups after treatment.（P<0.05）.Pang’s Gengnian An decoction modified prescriptions had more obvious advantages.4.Analysis of serum sex hormone levels in the two groups after treatment:There was a significant difference in the level of FSH between the two groups（P<0.05）,and the difference of E₂ level between the two groups was statistically significant（P<0.05）,suggesting that the curative effect of Pang’s Gengnian An decoction modified prescriptions is more obvious.Conclusion:Pang’s Gengnian An decoction modified prescriptions has obvious curative effect on peri-menopausal insomnia of yin deficiency and fire flourishing type.It can not only improve sleep,relieve its concomitant symptoms,but also regulate the level of serum sex hormones to a certain extent,so as to improve the quality of life of patients.There was no adverse reaction during treatment,the safety was good,the overall curative effect was better than that of the control group,and it was worthy of clinical application.