Age Differences In Auditory Perception In Schizophrenia And Bipolar Disorder

Objective Use ERP technology to explore the impairment of the auditory perception ability of patients with schizophrenia and bipolar disorder,as well as the characteristics and differences of auditory perception ability,to explore the characteristics and differences of auditory perception ability in patients with schizophrenia and bipolar disorder of different ages.difference.Methods 68 patients with schizophrenia,67 patients with bipolar disorder and 54 healthy controls between the ages of 18-70 were enrolled.The auditory MMN of the three groups of subjects in the oddball paradigm was detected,and their differences were analyzed.The difference in age between patients with schizophrenia and bipolar disorder.Using 3(different populations: patients with schizophrenia,patients with bipolar disorder,healthy controls)×3(age group: <35 years old,35-50 years old,>50 years old)two-factor betweengroup experimental design,the dependent variable is The magnitude of the subject’s EEG component MMN.Results(1)At the Fz and Cz electrode points,the MMN amplitudes of healthy subjects under 35 years old were significantly higher than those of the other two age groups(P<0.001,P<0.05).However,there was no significant difference in MMN amplitude between the 35-50 years old and over 50 years old age groups.(2)At the Fz and Cz electrode points,the MMN amplitude of patients with schizophrenia was significantly lower than the other two groups(P<0.05,P<0.05),and the MMN amplitude of patients with bipolar disorder was significantly lower than that of the healthy test group(P <0.001,P<0.001).(3)At the Fz and Cz electrode points,the MMN amplitudes of healthy controls in the age group under 35 were significantly greater than those of the other two disease groups(P<0.001,P<0.001).The differences in MMN amplitudes of patients in the two disease groups were marginally significant,and the MMN amplitudes of patients with bipolar disorder were greater than those of schizophrenia patients(P=0.065,P=0.062).In the 35-50 age group,the MMN amplitudes of healthy controls were significantly greater than those of the two disease groups(P<0.05,P<0.05),and the MMN amplitudes of patients with bipolar disorder were significantly greater than those of patients with schizophrenia(P<0.05,P<0.05).In the age group over 50,the MMN amplitudes of the healthy controls were significantly greater than those of the two disease groups(P<0.001,P<0.001),and there was no significant difference in the MMN amplitudes of the two disease groups.Conclusion The amplitude of MMN in healthy subjects showed a trend of accelerating and weakening with age,and then tending to flatten out.The MMN amplitude of patients with schizophrenia is the most severely damaged and tends to gradually weaken with age,while the MMN amplitude of patients with bipolar disorder is moderately damaged and gradually weakens with age,and then gradually weakens.Figure12;Table8;Reference 124...