| Objective: To determine the concentrations of 25-hydroxyvitamin D(25-(OH)D),immunoglobulin E(IgE),and interleukin 17(IL-17)in serum of children with bronchial asthma,and to analyze the relationship between the concentrations and the severity of bronchial asthma in children.To understand the relationship between serum 25-(OH)D concentration and serum IgE concentration,and IL-17 concentration in children with bronchial asthma.And to explore the role and clinical significance of 25-(OH)D,IgE,and IL-17 in the pathogenesis of asthma,to offer some scientific theoretical foundation for its prevention and treatment ofbronchial asthma in children.Methods: randomly selected in December 2019-November 2020 in jingzhou city central hospital,86 cases of pediatric hospital treatment included in the standard of bronchial asthma children in the experimental group,and then according to the condition of asthma severity,the experimental group and can be divided into three groups(mild duration 31 cases,moderate duration group 34 cases,31 cases of severe duration group).The normal control group was 64 normal children who were selected from the physical examination center of Jingzhou Central Hospital.Serum concentrations of 25-(OH)D,IgE,and IL-17 were measured in all children.1.According to the serum 25-(OH)D level,the patients were divided into vitamin D sufficient group,vitamin D insufficient group,and vitamin D deficiency group,and the number of patients in the experimental group and the normal control group were compared.2.The concentrations of 25-(OH)D,IgE,and IL-17 in serum of children in the experimental group and the normal control group were compared respectively;3.Serum 25-(OH)D concentration,IgE concentration,and IL-17 concentration were compared between mild asthma duration group,moderate asthma duration group,and severe asthma duration group and normal control group respectively,and the relationship between them and the severity of the disease was analyzed.4.Finally,the correlation analysis between serum25-(OH)D concentration and IgE concentration,25-(OH)D concentration,and IL-17 concentration was conducted.Results:(1)In the experimental group,there were 27 cases(31.40%)with sufficient serum 25-(OH)D concentration,31 cases(36.04%)with insufficient serum 25-(OH)D concentration,and 28 cases(32.56%)with insufficient serum 25-(OH)D concentration.In the normal control group,there were 32 patients(50.00%)with sufficient serum25-(OH)D concentration,21 patients(32.81%)with insufficient serum 25-(OH)D concentration,and 11 patients(17.19%)with insufficient serum 25-(OH)D concentration.0.05).(2)The serum concentration of 25-(OH)D in the experimental group(24.00±6.95)ng/ml was significantly lower than that in the normal control group(31.19±8.11)ng/ml,and the difference was statistically significant(P<0.01);The serum IgE concentration in the experimental group(205.75±67.12)IU/ m L was significantly higher than that in the normal control group(67.89±19.56)IU/ m L,and the difference was statistically significant(P<0.01);The serum IL-17 concentration of children in the experimental group(35.001±16.765)pg/ml was significantly higher than that in the normal control group(10.90±2.48)pg/ml,and the difference was statistically significant(P<0.01).(3)Serum 25-(OH)D concentration in the severe duration group(19.50±5.34)ng/ml was slightly lower than that in the moderate duration group(22.42±6.16)ng/ml,showing no statistical significance(P>0.05);The serum 25-(OH)D concentration in the moderate asthma group was(22.42±6.16)ng/ m L,which was significantly lower than that in the mild asthma group(28.78±5.94)ng/ m L,which was statistically significant(P<0.01);Serum IgE concentration in the severe duration group(274.58±45.11)IU/ m L was significantly higher than that in the moderate duration group(227.61±32.22)IU/ m L,and that in the mild duration group(135.15±35.47)ng/ m L,with statistically significant differences among the three groups(P<0.01);Serum IL-17 concentration in the severe duration group(51.15±21.11)pg/ml was significantly higher than that in the moderate duration group(35.18±10.87)pg/ml,and that in the mild duration group(23.86±7.65)pg/ml,and there were significant differences among the three groups(P<0.01).(4)Serum 25-(OH)D concentration was negatively correlated with serum IgE concentration in asthmatic children(r=-0.50,P<0.01);There was also a significant and negative correlation between serum 25-(OH)D concentration and serum IL-17concentration(r=-0.59,P<0.01).Conclusion:(1)The distribution of 25-(OH)D concentration in the experimental group was different from that in the normal control group,and vitamin D deficiency was relatively common in children with asthma.(2)The level of serum 25-(OH)D in asthmatic children was significantly lower than that in healthy children;Serum IgE levels were significantly higher than those of healthy children;Serum IL-17 levels were also significantly higher than in healthy children.(3)Serum 25-(OH)D concentration in the severe asthma duration group was lower than that in the moderate asthma duration group and lower than that in the mild asthma duration group,which was correlated with the severity of the disease.The serum IgE concentration in the severe asthma duration group was higher than that in the moderate asthma duration group and mild asthma duration group,which was correlated with the severity of the disease.Serum IL-17 concentration in the severe asthma duration group was higher than that in the moderate asthma duration group and mild asthma duration group,which was correlated with the severity of the disease.(4)There is a negative correlation between serum 25-(OH)D concentration and IgE concentration in children with asthma,and there is also a negative correlation between serum 25-(OH)D concentration and IL-17 concentration,which is of great significance in the mechanism of asthma. |
PDF Full Text Request