Analysis Of Regularity Of Traditional Chinese Medicine Treatment In Idiopathic Membranous Nephropathy Based On Data Mining

Objective:To summarize the medication experience of contemporary physicians in treatment of idiopathic membranous nephropathy through data mining technology.To analyze the characteristics of medication and compatibility rules of contemporary physicians in the treatment of IMN,in order to lay a foundation for IMN-related clinical and scientific research.Methods:Literature of IMN in the treatment of traditional Chinese medicine were collected,inducted and collated from the establishment of the library to December 2021 on CNKI,Wanfang Data Knowledge Service Platform,Weipu Journal,China Biomedical Literature Service System,Duxiu Academic Search,Superstar Journal,Pub Med and other electronic database resources.A total of 147 articles were collected.The number of cases,interventions,TCM evidence types,treatment methods and prescription drug composition,renal function,pathological staging,publication years and other information were extracted from the articles.The relevant information was entered into the Excel table to establish the IMN of Chinese medicine treatment Database.Excel was used to analyze the frequency of IMN’s syndrome types and performance of IMN Chinese medicines（four nature of drugs,five flavors,classification,meridians,etc.）,SPSS Modeler 18.0 and SPSS 26.0 were used to carry out correlation rules and cluster analysis of high-frequency drugs.Result:1.Statistical of the literature: a total of 147 articles were included.More men than women in the study.In terms of treatment,most clinical studies used traditional Chinese medicine and immunosuppressive therapy.The most common immunosuppressive treatment option were glucocorticoid and cyclophosphamide.In the literature which clearly proposed the range of blood creatinine,chronic kidney disease staging,and pathological staging requirements,most patients were serum creatinine <180μmol/l,CKD 1-3 stages,and Ⅰ-Ⅲ of pathological stages.2.The common traditional Chinese medicine syndromes of IMN: the main deficiency syndrome was mainly qi deficiency of spleen and kidney,followed by spleen and kidney deficiency,yang deficiency of spleen and kidney,qi and yin deficiency.The main symptoms were blood stasis syndrome,followed by dampness and blood stasis,damp-heat stasis,damp-heat syndrome.3.Frequency analysis: Among the 158 prescriptions,a total of 170 chinese medicines were used,and 1768 times were used.The drugs with a frequency of ≥ 20% were Astragalus,Poria,Atractylodes,Codonopsis,Angelica,Salvia,Chinese Yam,the rhizome of Chuanxiong,Lumbricus,Leech,Dogwood,Safflower,and Rehmannia.The top three of the four nature of drugs were warm,mild,and cold.The top three flavors were sweet,bitter,and spicy.The drugs were most often assigned to the liver,spleen,lung,and kidney channels.The top four drugs in the classification of drugs were tonic medicine,activating blood circulation and removing blood stasis drugs,diuretic dampness excreting medicine,and heat clearing drugs.Among the tonic drugs,qi was used more frequently.4.Analysis of association rules: There were 18 groups of two medicines,Astragalus and Codonopsis appeared the most cases,reaching 76 times,and the highest support was 47.79%.There were24 groups of three medicines,Astragalus,Codonopsis,and Poria appeared 46 times,with a support degree of 28.93%.5.Cluster analysis: A total of four clusters were obtained.The first group: Safflower,Peach kernel,Radix paeoniae rubra,Angelica,Ligusticum chuanxiong,Pheretima,Leech.The second group: Codonopsis,Epimedium,Astragalus.The third group:Dioscorea opposita,Dogwoods,Moutan bark,Alisma orientale,Radix rehmanniae.The fourth group: Oldenlandia diffusa,Coix seed,Poria,Atractylodes,Salvia,Semen euryales.Conclusion:The common TCM syndrome types of IMN were spleen-kidney qi deficiency,spleen-kidney yang deficiency,and qi-yin deficiency.Spleen-kidney qi deficiency and blood stasis syndrome was the most common type of IMN.Astragalus,Poria,Atractylodes,Codonopsis,Angelica,Salvia,Chinese yam,Chuanxiong,Dilong,and leech were the core drugs for the treatment of idiopathic membranous nephropathy.In the treatment of IMN,Traditional Chinese Medicines often added blood-activating,stasis-removing drugs,diuresis-dampening drugs,and heat-clearing drugs on the basis of tonic drugs in order to seek both temporary and permanent solutions.Astragalus – Codonopsis,Poria – Alisma,Astragalus-the rhizome of Chuanxiong – Angelica,Poria – Salvia-Atractylodes were commonly used drug combinations for the treatment of IMN.