| research objective:To observe the clinical effect of qiyishuquan Decoction on infantile monosymptomatic nocturnal enuresis of deficiency of spleen and kidney.Through a prospective cohort study,we compared the clinical symptom scores and the reduction times of enuresis before take qiyishuquanyin with aftert,analysed the recurrence rate of 3 months after take qiyishu quanyin,to clarified the clinical efficacy and safety of qiyishuquanyin for children with MNE.research method:From March 2021 to December 2021,children with enuresis who were treated for the first time in the outpatient depa rtment of Hubei Provincial Hospital of Traditional Chinese Medicine were selected.Based on real-world research,the enrolled patients were divided into two groups according to the treatment plan.In addition to drug treatment,each group of children received basic treatment for pediatric enuresis.-We recorded the basic data of the children,the changes of symptom scores and the reduction times of enuresis,and evaluated the curative effect of clinical symptoms before and after treatment,followed up the recurrence of enuresis within 3 months.We use Excel to input the collected data,to establish the database,and we use spss22 for statistical analysis.Research result:1.General information:A total of 82 cases were included,including 45 children who were treated with Qiyi Shuquan Decoction as the observation group,37 children treated with Shuquan Capsules as the control group,and finally 72 cases were observed.There were no significant differences in gender,age,disease course and family history between the two groups.2.Symptom scores: There was no statistical difference between the observation group and the control group in the total symptom score before treatment,the main symptom score（weekly frequency of enuresis,the amount of enuresis at night,and the degree of arousal during enuresis）and the subsymptom score（P>0.05）.After treatment,the scores of total symptoms,main symptoms and secondary symptoms in the two groups were decreased（P<0.01）.The scores of total symptoms and main symptoms in the observation group decreased more significantly than those in the control group after the 4th week（P<0.01）.The scores of secondary symptoms decreased significantly after the 12 th week（P<0.01）.3.Reduction in the frequency of enuresis: 40 cases（93.02%）in the observation group were clinically cured,and 18cases（62.20%）in the control group were clinically cured, and the efficiency of reducing the number of enuresis was significantly different（P<0.01）.There was no significant difference in the time to reduce enuresis between the two groups.4.The rate of recovery and remarkable effect of the two groups: after 12 weeks of treatment,the rate of the observation group was（93.02%）,and that of the control group was（51.72%）.The rate of the observation group was higher than that of the control group（P < 0.01）.5.The drop-off rate of the two groups was higher in the control group than in the observation group（P<0.05）.6.Safety assessment : During the treatment,there were no adverse reactions in the two groups of pati-ents,and the indicators such as urine routine,liver and kidney function were all within the normal range.7.Recurrence rate: After 3 months of follow-up,there were 11/40 cases of recurrence in the observation group（27.50%）and 4/18 case of recurrence in the control group（22.22%）There was no difference in the recurrence rate of enuresis between the observation group and the control group（P>0.05）.conclusion:1.Through the clinical cohort study,the two regimens have curative effect in the treatment of enuresis in children,and both can reduce the frequency of enuresis in children,and no obvious adverse reactions were observed.2.Compared with Shuquan Capsule,Qiyi Shuquan Decoction is better than Shuquan Capsule in the initial treatment effect（reduced frequency of nocturnal enuresis）in children with enuresis syndrome of spleen and kidney deficiency.It is better than Shuquan Capsules in terms of relieving the overall and main symptoms of the disease（frequency of enuresis at night,degree of nighttime awakening,and reduction of nighttime urine output）in the short-term.3.In terms of the treatment of combined symptoms in children with enuresis of spleen and kidney deficiency type,Qiyishuquanyin is more effective than Shu quan Capsule after 12 weeks.4.The recurrence rate of Qiyi Shuoquan Decoction and Shu quan Capsules in children with enuresis syndrome of spleen and kidney deficiency within 3 months is the same.The oral treatment of Qiyishuqu anyin in the treatment of MNE with spleen and kidney deficiency is clear and safe,which is worthy of clinical appli-cation. |
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