| Objective: To test whether serum soluble growth stimulator gene 2 protein(sST2)can predict the complexity of coronary artery disease in patients with acute coronary syndromes(ACS),we analyzed a retrospective study between sST2 and the severity of coronary artery disease in patients with acute coronary syndrome.Methods: 173 ACS patients diagnosed as ACS and underwent primary coronary angiography from July 1,2018 to December 31,2018 in the First Affiliated Hospital of Nanjing Medical University were enrolled in this study.According to the diagnostic criteria in the 2019 edition of "Acute Coronary Syndrome Emergency Rapid Diagnosis and Treatment Guidelines",the patients were divided into unstable angina pectoris(UA)group,acute ST segment elevation myocardial infarction(STEMI)group and non ST segment elevation myocardial infarction(non ST segment elevation myocardial infarction)group.85 patients with negative results of coronary angiography were selected as control group.Total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C),lipoprotein a [Lp(a)],sST2,NT-pro BNP,Killip classification of cardiac function,troponin T(c Tn T),left ventricular end diastolic diameter(LVDd),left ventricular ejection fraction(EF)value and Gensini score were collected.The correlation between sST2,NT-pro BNP and Gensini score was analyzed.Receiver Operating Characteristic Curve(ROC)was used to evaluate the expression of sST2 in patients with ACS.Results: Compared with the control group,there was no significant difference in the level of sST2 in UA group,but the level of sST2 in STEMI group and NSTEMI group was significantly higher(P< 0.05),the level of sST2 in STEMI group was higher than that in NSTEMI group(P< 0.05);area under curve(AUC)of sST2 expression in patients with ACS was 0.844,the sensitivity was 77.5%,and the specificity was 81.2%.Compared with the control group,Gensini score of ACS patients was higher,and NSTEMI group was higher than UA group and STEMI group(P< 0.05),serum sST2 level was positively correlated with Gensini score(rs =0.586,(P< 0.001).Compared with the control group,the NT-pro BNP in STEMI group and NSTEMI group was significantly higher than that in the control group(P <0.05).There was a significant positive correlation between NT-pro BNP and Gensini score(rs = 0.680,P < 0.001).Conclusion: There is a significant correlation between serum sST2 and the complexity of coronary artery lesions in patients with ACS.sST2 can be used as a novel biomarker to predict the severity of coronary artery lesions in ACS patients.NTpro BNP was positively correlated with the complexity of coronary artery lesions in ACS patients. |
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