Research On Blood Coagulation Process Test Method Based On Pressure Detection

There is a dynamic equilibrium among coagulation,anticoagulation and fibrinolysis in normal human body,and the occurrence of many blood-related diseases,such as cardiovascular and cerebrovascular diseases,thrombotic diseases and hyperfibrinolysis diseases,is closely related to this dynamic imbalance.Therefore,detection of blood-related diseases is of great significance in clinical practice.Human body blood coagulation process is relatively complex,platelets,tissue factor and thrombin regulate and balance each other.At present,coagulation tests are mainly conventional coagulation tests and thromboelastography(TEG)tests,the samples of conventional coagulation tests are plateletpoor plasma,which weakens the role of platelets in blood coagulation,and is the detection of one or several coagulation factors,which cannot truly reflect The whole picture of coagulation,so some scholars have proposed the detection based on whole blood,and TEG is the main detection method in China.However,TEG equipment has complex mechanical structure,high requirements for assembly accuracy and high processing technology of core components,so its full automation cannot well meet clinical requirements.In view of this,this subject proposes a test method for blood coagulation process based on pressure detection.This topic introduces the principle of the domestic mainstream whole blood detection method in detail,analyzes the characteristics of blood coagulation,and proposes a method that utilizes gas pressure to deform the thin layer of blood,and indirectly reflects the blood coagulation process by detecting the pressure change.The feasibility of this research method was verified by finite element simulation analysis.At the same time,a mathematical model was established to describe the coagulation process of different types of blood samples by fitting the thrombus elasticity diagram curve of normal and abnormal blood samples.Using the experimental platform,experiments were designed and better experimental parameters were explored.Finally,the sensitivity of this method to the detection of blood coagulation process was verified by comparing the method with TEG method.The experimental results show that the research method has a high degree of similarity with the curve obtained by TEG equipment,and the two methods have a good consistency in the measurement of R value,K value,Angle value and MA value.The possibility of mutual substitution exists between the two methods,and the pneumatic method can detect the coagulation process of blood.