| Objective:Prevention and treatment of ischemic stroke has always been an important part of global public health management.The risk and prognosis of ischemic stroke may vary widely among patients because of the number and severity of combined risk factors.Most previous studies have failed to comprehensively combine hematological indicators,scales,and imaging features.To investigate the possible factors affecting the short-term prognosis of patients with ischemic stroke,we based on the early hematological indicators changes and imaging characteristics of ischemic stroke patients,and also combined with traditional risk factors such as stroke complication,genetics,smoking and alcohol consumption.Finally,we compared the differences for different patients outcomes in short-term prognosis.Methods:1,866 patients who were diagnosed as acute ischemic stroke（AIS）were enrolled in Department of Neurology of Xing’an League People’s Hospital from November 2019 to October2020 as object of study.We collected information such as patients general information（including:age,gender,height,weight,ethnicity,marital status,hyperlipidemia,diabetes,atrial fibrillation,hypertension,history of smoking,history of drinking,etc.）,relevant laboratory indicators（including white blood cell count and classification,lipid levels,kidney function,inflammatory factors,fasting blood glucose,etc.）,imaging data and relevant scale data.Patients were divided into good prognosis group and poor prognosis group according to their prognosis.Logistic regression analysis was used to explore the correlation between the prognosis of patients and each indicator separately at the time of patient discharge and at the follow-up visit 3 months after patient discharge.We analysis the effect of various indicators on the short-term prognosis of patients with ischemic stroke.Statistically significant differences were set at P<0.05.Results:1.Patients were diagnosed with a good prognosis group of 1726（92.5%）and a poor prognosis group of 140（7.5%）at discharged.Single factor analysis showed that the poor discharge prognosis group differed statistically from the good discharge prognosis group in terms of gender,course of hypertension,BMI,NIHSS score,drinking water test score,ADL score,glucose,cholesterol,white blood cells,uric acid and C-reactive protein（P<0.05）.2.Patients were diagnosed with a good prognosis in the group of 1642（88.0%）and a poor prognosis in the group of 224（12.0%）at discharged 3 months later.Single factor analysis showed that the poor prognosis group differed statistically from the good prognosis group in terms of gender,BMI,NIHSS score,drinking water test score,ADL score,glucose,white blood cells,urea and C-reactive protein（P<0.05）.3.Many indicators correlate with poor patient prognosis at hospital discharge,such as NIHSS score,drinking water test score,blood glucose,white blood cells and uric acid.Patients with ischemic stroke who NIHSS scores in subgroups 7-15 and 16-42 had a higher risk of poor prognosis after hospital discharge compared to those in subgroups 0-6（OR（95%CI）=1.83 [1.05,3.23],3.75 [1.72,8.16]）.Patients with ischemic stroke who drinking water test score in ≥ 3subgroup had a higher risk of poor prognosis after hospital discharge compared to those in subgroup<3（OR（95%CI）=2.21 [1.35,3.62]）.Compared with patients who were allocated to normal glucose level group,patients with ischemic stroke in the high glucose level group had a higher risk of poor prognosis after discharge（OR（95%CI）=2.37 [1.46,3.84]）.Compared with patients who were allocated to normal WBC level group,patients with ischemic stroke in the high WBC level group had a higher risk of poor prognosis after discharge（OR（95%CI）=2.35 [1.56,3.55]）.Compared with patients who were allocated to normal uric acid level group,patients with ischemic stroke in the high uric acid level group had a lower risk of poor prognosis after discharge（OR（95%CI）=0.35 [0.17,0.73]）.4.Many indicators correlate with poor patient prognosis at 3-month follow-up after hospital discharge,such as NIHSS score,drinking water test score,blood glucose,white blood cells,gender.Women with ischemic stroke have a higher risk of poor prognosis than men at 3-month follow-up after hospital discharge（OR（95%CI）=1.40 [1.05,1.88]）.Patients with ischemic stroke who NIHSS scores in subgroups 7-15 and 16-42 had a higher risk of poor prognosis compared to those in subgroups 0-6 at 3-month follow-up after hospital discharge（OR（95%CI）=1.42 [0.90,2.24],2.42 [1.21,4.84]）.Patients with ischemic stroke who drinking water test score in ≥ 3subgroup had a higher risk of poor prognosis compared to those in subgroup <3 at 3-month follow-up after hospital discharge（OR（95%CI）=1.59 [1.05,2.41]）.Compared with patients who were allocated to normal glucose level group,patients with ischemic stroke in the high glucose level group had a higher risk of poor prognosis at 3-month follow-up after hospital discharge（OR（95%CI）=1.54 [1.11,2.14]）.Compared with patients who were allocated to normal WBC level group,patients with ischemic stroke in the high WBC level group had a higher risk of poor prognosis at discharged 3 months later（OR（95%CI）=1.44 [1.02,2.03]）.Conclusion:1.Some indicators are associated with poor prognostic outcomes at hospital discharge in patients with acute ischemic stroke.Such as NIHSS score,drinking water test score,blood glucose,white blood cells,uric acid levels.As the risk factors,Some indicators are positively associated with the severity of poor prognosis at hospital discharge in patients with acute ischemic stroke.Such as NIHSS score,drinking water test score,blood glucose,white blood cells.As a protective factor,uric acid levels are negatively associated with the severity of poor prognosis at hospital discharge in patients with acute ischemic stroke.2.Some indicators are associated with poor prognostic outcomes at 3-month follow-up after hospital discharge in patients with acute ischemic stroke.Such as gender,NIHSS score,drinking water test score,blood glucose,white blood cells.As the risk factors,Some indicators are positively associated with the severity of poor prognosis at 3-month follow-up after hospital discharge in patients with acute ischemic stroke.Such as NIHSS score,drinking water test score,blood glucose,white blood cells.Female patients are more likely to have a poor prognosis at the3-month follow-up after hospital discharge than male patients.3.Some indicators are common influencing factors in the prognosis of acute ischemic stroke patients after hospital discharge and at 3 months after discharge.Such as NIHSS score,drinking water test score,blood glucose,white blood cells. |
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