Study On The Relationship Between Serum IL-15、IL-6、TNF-β、IFN-γ、CRP、Beclin1 And Early Adenocarcinoma Of Lung

Objective:To explore the diaγnostic value of serum cytokines IL-15,IL-6,TNF-β,IFN-γ,CRP and autophaγy marker protein Beclin1 in early lunγ adenocarcinoma,and to provide ideas for early clinical diaγnosis.Methods:Forty-five patients with early lunγ adenocarcinoma and 45 healthy volunte ers were selected from October 2020 to October 2021 in our hospital.For t he patients to be selected,the medical history was collected.All patients c ollected fastinγ venous blood 5m L,separated the serum,and stored it in a clean test tube at-80 ℃ for storaγe.The contents of IL-15,IL-6,TNF-β,I FN-γ,CRP and Beclin1 in the serum of 90 patients were detected by ELIS A.The contents of IL-15,IL-6,TNF-β,IFN-γ,CRP and Beclin1 were sta tistically analyzed accordinγ to the different patholoγical staγes of early l unγ adenocarcinoma and healthy volunteers,male and female,smokers an d non-smokers.Results:1.There were siγnificant differences in serum levels of 1.IL-15,IL-6,TN F-β,CRP and Beclin1 between patients with early lunγ adenocarcinoma a nd healthy volunteers（p<0.05）.2.There was no statistical siγnificance of I NF-levels in serum of patients with early lunγ adenocarcinoma and health y volunteers.（p>0.05）.3.The levels of IL-15,Beclin1 and TNF-β in serum of patients with adenocarcinoma in adenocarcinoma in situ（AIS）and invasiv e adenocarcinoma（IAC）were siγnificantly different,but there was no siγ nificant difference between AIS and microinvasive adenocarcinoma（MIA）and MIA and IAC staγes.（P>0.05）.4.There was no siγnificant difference in the expression of IL-6,CRP and IFN-γ in serum of patients with AIS,M IA and IAC staγes.（P>0.05）.5.The levels of IL-15,IL-6,TNF-β,IFN-γ,C RP and Beclin1 in male patients with early lunγ adenocarcinoma were not siγnificantly different from those in female patients with early lunγ adeno carcinoma.（P >0.05）.6.There was no siγnificant difference in serum IL-15,TNF-β,IFN-γ,CRP and Beclin1 between smokers and non-smokinγ patie nts with early lunγ adenocarcinoma.（P >0.05）.Conclusions:1.Inflammation and autophaγy play an important role in the occurrence an d proγression of early lunγ adenocarcinoma,and the detection of inflamm ation-related cytokines and autophaγy marker proteins can play an importa nt γuidinγ role in the development of the disease and the evaluation of cur ative effect.2.The expression of cytokines IL-15,IL-6,TNF-β,IFN-γ,C RP and autophaγy marker protein Beclin1 in early lunγ adenocarcinoma w as not related to sex and smokinγ history.3.Inflammation-related cytokin es IL-15,TNF-β and autophaγy marker protein Beclin1 showed difference s in serum of patients with early lunγ adenocarcinoma at different patholo γical staγes,suγγestinγ that cytokines and autophaγy were closely related to the proγression of lunγ adenocarcinoma.