| ObjectiveIn recent years,the prevalence rate of diabetes is increasing rapidly,which in China is as high as 11.6%in adults.However,if diabetes is not well controlled,it is easy to cause various chronic complications,seriously harm people's quality of life,and bring heavy economic burden to everyone.Diabetic kidney disease,as one of the chronic complications of diabetes,makes people begin to actively seek treatment methods other than drugs because of its rapid progress,high mortality rate and the lack of effective treatment at present.And exercise is a good alternative.Based on the present situation,this study designed a set of TCM syndrome differentiation exercise prescription according to the requirement of kidney disease patients,in order to prove its safety and effectiveness and protect renal function.Previous studies have shown that exercise is beneficial to patients with early diabetic kidney disease,but there is no evidence of evidence-based medicine for exercise style,exercise time and exercise intensity.The purpose of this study is to provide a referential procedure for early diabetic kidney disease patients.MethodRecruit volunteers to meet the test criteria,obtain informed consent,ask about the relevant medical history,complete the group test including blood routine,renal function,blood glucose,blood lipid,glycosylated hemoglobin,Urinary albumin(stage ? of DKD)or 24 hour urinary protein quantitative detection(stage ?1 of DKD)and related body physical test,plus pre-exercise risk assessment questionnaire,short international physical activity questionnaire,TCM syndromes score form,and Memorial University of Newfoundland Scale of Happiness(MUNSH),etc.According to the random sampling method,the patients were divided into 2 groups including the test group and the control group,then the test group entered the guidance period for 12 weeks.The patients were trained at least 2-3 times a week in the first 1-2 weeks to ensure the completeness and accuracy of the action,and complete the whole actions at least once every two days,about 20 minutes per day.From week 3 to week 12,correct all actions at least once a week face to face,on the basis of skillful movement,the rest of the activities should be completed at home for more than half an hour(at least once)per day,and the activity time may be between half an hour and one hour after a meal,or according to one's own blood glucose,according to the professional's suggestion,Once a week via telephone or WeC hat group feedback should be completed,also communicate with each other.After 12 weeks,we would ask the recent medication adjustment,completed the group test and questionnaire survey(same as entering the group).Result1 Glycosylated hemoglobin:compared with pre-intervention,the level of glycosylated hemoglobin decreased significantly,but there was no significant difference from that of the control group.2 Rinary protein related indexes(including u-alb and ACR in patients with stage III of DKD,24hUTP in patients with stage ?1 of DKD):There was not significantly difference from those pre-intervention.3 Body weight related indexes:BMI,waistline and waist-to-hipratio were significantly decreased from pre-intervention in the test group,and there were significant differences between the two groups.4 Physical Fitness:the maximal oxygen uptake,sitting position flexion,standing on one foot closed eyes and reaction time in the test group were significantly improved as compared with those of pre-intervention,and the difference was significantly discrepant from that in the control group.5 Weekly physical activity level:the weekly physical activity level of the experimental group increased significantly after intervention,and the difference of it was also significant compared with the control group.6 TCM syndromes integral table:after intervention,the scores of TCM in the test group were significantly improved,and the degree of improvement was also significantly different from that of the control group.7 Happiness:after intervention,the happiness of the patients in the trial group was obviously improved,and the difference between the two groups after intervention was significant.Conclusion1 The control of blood glucose in early DKD patients is unstable,and it is easy to cause the progression of nephropathy,even after the drug adjustment the effect is not satisfactory.2 In the test group,the exercise was done in accordance with the exercise prescription of TCM syndrome differentiation set by the researchers,and the body weight,blood glucose,glycosylated hemoglobin,urine protein and other important effective indexes were improved or delayed to some extent,and the weekly physical activity level increased.Physical fitness also has a greater improvement,happiness advanced,Chinese medicine symptoms relieved. |
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