Effects Of Tongluo Huazhuo Pills On Dyslipidemia Patients With Phlegm And Blood Stasis Syndrome And Its Mechanism

Objective:To investigate the clinical significance and effective mechanism of action of Tongluo Huatuo Pill in treating patients with dyslipidemia,phlegm and stasis.Methods:A total of 120 outpatients or inpatients who met the diagnostic criteria of Chinese and Western medicine in the First Affiliated Hospital of Hunan University of Traditional Chinese Medicine from December 2019 to December 2020 were selected,and the included patients were divided into treatment and control groups of60 cases each according to the random number table method.The patients in both groups were treated with the basic treatment method,on top of which the treatment group was treated with Tongluo Huatuo pill,10 grams each time,twice a day;the control group was treated with Atorvastatin Calcium Tablets,20 mg each time,once a day,and both groups were treated continuously for 12 weeks.By observing the changes of the total TCM symptoms score,TCM symptoms efficacy,blood lipid index,total blood lipid efficacy and the changes of LCAT and LPL activity before and after treatment in both groups,statistical methods were applied to draw conclusions to evaluate the efficacy and mechanism of action of Tongluo Huatuo pill in patients with dyslipidemia,phlegm and stasis evidence.Results:(1)Comparing the total TCM symptom scores,the TCM symptom scores of both the treatment group and the control group decreased after treatment,but the effect of the treatment group was better than that of the control group.(2)Comparing the efficacy of TCM symptoms,the total effective rate in the control group was lower than that in the treatment group(P < 0.05),indicating that the total efficacy of TCM symptoms in the treatment group was better than that in the control group.(3)Comparing the changes of lipid indexes,we compared the lipid indexes of patients with mild,moderate and severe dyslipidemia within the group,and found that TC,TG and LDL-C decreased and HDL-C increased in both groups after treatment(P <0.05),indicating that both groups have therapeutic effects on patients with mild,moderate and severe dyslipidemia;comparing the lipid indexes of patients with mild and moderate dyslipidemia between the groups,we found that after 6 and 12 weeks of treatment(P > 0.05),indicating that the two groups had comparable efficacy in regulating the lipid indexes of mild and moderate dyslipidemia;comparing the lipid indexes of patients with severe dyslipidemia between groups,P < 0.05 was found after 6 and 12 weeks of treatment,indicating that the control group had better efficacy than the treatment group in regulating the lipid indexes of severe dyslipidemia.(4)The total efficacy of lipid was 86.6% in the treatment group compared with 90% in the control group(P>0.05),indicating that there was no statistical difference between the two groups in improving the total efficacy of lipid in patients with dyslipidemia,phlegm and stasis.(5)Comparison of LPL and LCAT,the LPL and LCAT activity of both the treatment group and the control group increased after treatment(P < 0.05),indicating that both groups had an improvement effect on LPL and LCAT activity;the comparison between groups showed that the increase of LPL and LCAT activity of the treatment group was better than that of the control group(P < 0.05),indicating that the improvement of LPL and LCAT activity of the treatment group The comparison between groups showed that the increase of LPL and LCAT activity in the treatment group was better than that in the control group(P < 0.05),indicating that the improvement of LPL and LCAT activity in the treatment group was better than that in the control group.(6)During the treatment period,no significant side effects were observed in both groups.Conclusion:In patients with dyslipidemia of phlegm and stasis type,Tongluo Huatuo Pill can improve patients’ TCM clinical symptoms,increase LCAT and LPL activity more effectively compared with atorvastatin,and has the effect of regulating blood lipid level effectively,with no significant adverse effects during the observation period and good clinical efficacy.