| Objective:To investigate the changes of plasma soluble(pro)renin receptor(S(P)RR)levels in patients with different types of chronic heart failure and its relationship with prognosis.Methods:112 CHF patients(HF group)in our hospital and 21 healthy people(control group)in the physical examination center were selected.According to the 2018 Chinese guidelines for the diagnosis and treatment of heart failure,HF group was divided into three subgroups:HFrEF group(45 cases in group A),HFmrEF group(20 cases in group B)and HFpEF group(47 cases in group C).The plasma S(P)RR levels of each group were determined by enzyme-linked immunosorbent assay(ELISA).Analysing the differences of plasma S(P)RR levels among HF group and control group and each subgroup,and evaluating the correlation between S(P)RR levels and prognosis combined with follow-up.Results:The plasma S(P)RR level in HF group was significantly higher than that in normal control group(P<0.05).The levels of S(P)RR in group A?B and C were significantly higher than those in normal control group.The level of S(P)RR in group A was higher than that in group B and C(P<0.05),and the level of S(P)RR in group B was higher than that in group C(P<0.05).Combined with the follow-up results,the plasma S(P)RR level of readmission HF patients was significantly higher than that of non-readmission HF patients(P<0.05).Pearson correlation analysis showed that LVEF was negatively correlated with S(P)RR(P<0.05),and S(P)RR was positively correlated with NT-proBNP(P<0.05).Conclusion:S(P)RR is closely related to heart failure,the level of plasma S(P)RR can reflect the severity of heart failure to a certain extent,and has a certain reference value in judging the prognosis. |
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