Investigation Of TCM Constitution In Patients With Osteoarthritis And Its Correlation With Syndrome Types

Purpose:By observing the distribution characteristics of TCM Constitution and TCM syndrome types of patients with osteoarthritis(OA),and combining with the general information and various indicators of patients,this paper discusses the distribution law and correlation of TCM Constitution and TCM syndrome types of patients with osteoarthritis,analyzes the potential factors of OA,and provides new ideas for the prevention and treatment of the disease.Research method:1.Methods: 248 OA patients hospitalized in the Department of Rheumatology,Affiliated Hospital of Liaoning University of traditional Chinese medicine from September 2019 to September 2020 were selected as the research objects.According to the Constitution and classification judgment table of traditional Chinese Medicine published in 2009,the constitution of the patients was determined,and according to the TCM Syndrome judgment standard of diagnosis and treatment scheme of osteoarthritis(osteoarthritis)issued by the State Administration of traditional Chinese medicine in 2010,the syndrome types of the patients were determined Judgment.2.The patients were instructed to evaluate their own joint pain with visual analogue scale(VAS)score,and the general information,ESR,C-reactive protein,bone mineral density,blood lipid levels and other clinical indicators were collected.3.Input the above data into excel 2019 and use SPSS 26.0 for statistics and analysis.Results:In terms of TCM Constitution:1.There were 366 times of each constitution,of which the frequency of Yang deficiency was the most 82 times(22.40%),followed by qi deficiency 81 times(22.13%),phlegm dampness67 times(18.31%)and yin deficiency 49 times(13.39%).Among 248 OA patients,145 cases(58.47%)were simple constitution,among which 41 cases(27.70%)were Yang deficiency constitution,followed by 28 cases(19.31%)of qi deficiency constitution,25 cases(17.24%)of phlegm dampness constitution and 20 cases(13.79%)of yin deficiency constitution;103cases(41.53%)were complex constitution,among which 15 cases(15.79%)were Qi deficiency constitution + Yin deficiency constitution,followed by 14 cases(14.74%)of Yang deficiency constitution + phlegm dampness constitution There were 12 cases(12.63%)with Qi deficiency and yang deficiency,and 10 cases(10.53%)with Qi deficiency and phlegm dampness.2.In the above simple constitution,the BMI level of phlegm dampness constitution was higher than that of the other three constitutions(P < 0.05),the BMI level of yin deficiency constitution was lower than that of the other three constitutions(P < 0.05),the total cholesterol level of phlegm dampness constitution was significantly higher than that of Yin deficiency constitution(P < 0.05),and the VAS score of Yang deficiency constitution was higher than that of yin deficiency constitution(P < 0.05);in the above complex constitution,the BMI of qi deficiency constitution and phlegm dampness constitution was higher than that of yin deficiency constitution(P < 0.05)The VAS score of Yang deficiency + phlegm dampness was higher than that of qi deficiency + Yin deficiency(P < 0.05);there was no significant difference in other indexes between two constitutions(P > 0.05).In terms of TCM syndrome types:1.The frequency of TCM syndrome types of 248 OA patients from high to low was cold dampness obstruction syndrome(36.29%)> liver and kidney deficiency syndrome(33.06%)> damp heat block syndrome(10.89%)> Qi and blood deficiency syndrome(10.08%)> phlegm and blood stasis syndrome(9.68%).2.The results showed that the proportion of female patients with cold dampness obstruction syndrome(41.11%)was significantly higher than that of male patients(23.53%),the difference was statistically significant(P < 0.05);there was statistical difference between the syndrome types in patients with disease course of 0-5 years and > 10 years(P < 0.05);the proportion of cold dampness obstruction syndrome was the highest in 0-5 years(51.25%);the proportion of liver and kidney deficiency syndrome was the highest in > 10 years(42.72%)There were significant differences between mild pain and severe pain(P < 0.05),and the highest proportion of mild pain was liver and kidney deficiency(49.33%);the highest proportion of severe pain was cold dampness obstruction(47.37%);there were significant differences between normal BMD and osteoporosis(P < 0.05),and the highest proportion of normal BMD was cold dampness obstruction(57.33%)65%);the highest proportion of osteoporosis was liver and kidney deficiency syndrome(41.57%);the VAS score of patients with cold dampness obstruction syndrome was significantly higher than that of patients with liver and kidney deficiency syndrome,dampness heat block syndrome and phlegm and blood stasis syndrome(P < 0.05),and there was no significant difference in other indicators between each syndrome type(P > 0.05).The correlation between constitution and syndrome type was as follows:The chi square test showed that the distribution relationship between different constitutions and different syndrome types of OA patients in this study was statistically significant(P <0.05);the correspondence analysis between TCM Constitution and TCM syndrome types of OA patients showed that liver and kidney deficiency syndrome was closely related to Qi deficiency and yin deficiency;cold dampness obstruction syndrome was closely related to Yang deficiency and phlegm dampness;damp heat block syndrome was closely related to damp heat syndrome;Phlegm and blood stasis syndrome is closely related to phlegm dampness,blood stasis and qi stagnation;Qi deficiency syndrome is closely related to Qi deficiency and yin deficiency.Conclusion:1.The total constitution type and simple constitution of OA patients are mainly Yang deficiency,followed by qi deficiency,phlegm dampness and yin deficiency.2.In the patients with complex constitution,Qi deficiency + Yin deficiency was the main type,followed by Yang deficiency + phlegm dampness,Qi deficiency + Yang deficiency and Qi deficiency + phlegm dampness.3.TCM syndrome types are mainly cold dampness obstruction syndrome,followed by liver and kidney deficiency syndrome,damp heat block syndrome,Qi and blood deficiency syndrome and phlegm and blood stasis syndrome.4.TCM syndrome types of patients are closely related to TCM Constitution,among which liver and kidney deficiency syndrome is closely related to Qi deficiency and yin deficiency syndrome;cold dampness obstruction syndrome is closely related to Yang deficiency and phlegm dampness syndrome;damp heat block syndrome is closely related to damp heat syndrome;phlegm and blood stasis syndrome is closely related to phlegm dampness syndrome,blood stasis syndrome and qi depression syndrome;Qi deficiency syndrome is closely related to Qi deficiency and yin deficiency syndrome.