Application Of Electrospun Fluorescent Nanofibers In Drug Release And Monitorin

The development of nanomedicine biotechnology,which provides effective means for drug delivery on demand and controlled release,has attracted extensive attention.The realtime information on drug release amount can be obtained by monitoring the drug release process with fluorescence,which is of great significance for practical treatment.The fluorescence monitoring function is usually realized by doping the fluorescence particles into the nanofibers.It is convenient and fast to prepare the organic nanofibers with fluorescence function by electrostatic spinning technology.With the wide application of fiber in nanomedicine and fluorescence monitoring,new functions and applications of nanofibers are expected to be higher.For example,innovations in drug delivery and drug monitoring.Therefore,this paper introduces the application of two fluorescent nanofibers as controlled release drugs for anticancer drugs.We designed a drug stimulus delivery system.Firstly,upconversion fluorescent nanoparticles were synthesized by hydrothermal method,and the upconversion nanoparticles were doped into l-polylactic acid(PLLA)nanofibers by electrostatic spinning.These organic nanofibers have excellent upconversion luminescence properties.Further amino modification of these organic nanofibers leads to higher drug loading and controllable drug release rate.The drug release rate of the drug-loading fiber could be further regulated by p H,which showed relatively accelerated drug release in an acidic environment,while the p H value of the tumor site showed weak acidity,which was conducive to drug release.Its main mechanism is attributed to the chemical bond formed between the molecule of doxorubicin hydrochloride(DOX)and the amino group.To further develop a controlled drug delivery system,we designed another drug delivery system.The composite nanofiber membrane which can be loaded with drugs was prepared with hydrogel and nanofiber.Through stimulating response,drugs can be released according to needs,and the relationship between drug release amount and disease recovery can be monitored in real-time,to better guide drug dosage.In this study,the thermalsensitive hydrogel was selected,and photothermal material MXene was added to the hydrogel.A device was designed to maintain the temperature at the phase transition point of the hydrogel during the preparation process so that the thermosensitive hydrogel was always flowing.Photostimulation-responsive MXene@Hydrogel composite nanofiber membranes were prepared by electrospinning fluorescent nanofibers on one side and electrospraying hydrogel on the other side.Due to the photothermal properties of composite nanofibers,the rheological properties of hydrogels can be controlled by light,thus controlling the release rate of drugs.The experimental results show that a hydrogen bond is formed between MXene and Hydrogel,and the mechanical properties of composite nanofiber materials are significantly enhanced,which is beneficial to the application of human joints and other parts that need to move.We propose fluorescence monitoring of drug release to achieve real-time monitoring of patients in different microenvironments,which cannot be achieved by drug release curves measured by traditional absorption spectra.