Preparation Of Metal-tannin Supramolecular Composite Nanomaterials And Applications In Blood Glucose And Drug Analysis

Accelerating charge transfer and mass transport in reactions has been a research hotspot for improving the catalytic activity of electrocatalysts.Tannic acid（TA）could coordinate with metal ions on the surface of the substrate,forming supramolecular metal-tannin networks.On one hand,the obtained supramolecular networks have abundant metal catalytic centers.On the other hand,it could accelerate the charge transfer on the surface of the catalyst and enhance the reactant adsorption of the catalyst.In addition,its preparation is green and simple and can introduce one or even multiple metal ions at the same time.In recent years,it has been commonly used as a multifunctional surface modification material.This thesis adopts the coordination-driven self-assembly method to coat metal-tannin networks on carbon hybrid nanoparticles and nanofibers,respectively.Moreover,it analyzes the physicochemical and electrochemical properties of metal-tannin networks,and evaluates the electrocatalytic performance of the prepared catalyst in blood glucose and drug analysis.The specific research contents are as follows:（1）Cr₂O₃ nanoparticles hybridized by carbon（C-Cr₂O₃ NP）were prepared by the hydrothermal-carbonization method.With the Ni-TA networks self-assembled on the surface,the prepared C-Cr₂O₃ NP@Ni-TA can be used for the electrocatalytic oxidation of glucose.Research suggests that the Ni-TA networks with a thickness of only 1～2 nm could significantly accelerate the charge transfer on the surface of C-Cr₂O₃ NP.Under optimal experimental conditions,C-Cr₂O₃ NP@Ni-TA exhibits high sensitivity(5043.3μA·m M^-1·cm^-2)and low detection limit（0.02μM）for glucose detection.Moreover,C-Cr₂O₃ NP@Ni-TA exhibits excellent selectivity,stability,and reproducibility,which can efficiently and accurately analyze human plasma samples.（2）Ce O₂ nanofibers hybridized by carbon（Ce O₂ CNF）were prepared by the electrospinning method.With the Ni-TA networks self-assembled on the surface,the prepared C-Ce O₂ CNF@Ni-TA can be used for the electrocatalytic oxidation of isoniazid（INZ）and hydrazine（HYD）.Research suggests that the Ni-TA networks could enhance the mass transport of INZ and HYD on the surface of C-Ce O₂ CNF and effectively reduce the interface resistance.Under optimal experimental conditions,Ce O₂ CNF@Ni-TA exhibits a low detection limit for the detection of INZ（0.012μM）and HYD（0.008μM）.Moreover,Ce O₂CNF@Ni-TA exhibits excellent selectivity,stability,and reproducibility,which could efficiently and accurately analyze human plasma and urine samples.This work discusses the influence of the supramolecular metal-tannin network on the electrocatalytic activity of the nanomaterial.It demonstrates that the supramolecular metal-tannin network can enhance the electronegativity,adsorption,hydrophilicity and other characteristics of the nanomaterial,improves the charge transfer and mass transport between the material and the electrolyte,and shows great application potential in the electrochemical sensing of blood glucose and drug.