Research On TENG For Electric Field Control Of Tumor Cells

The application of friction nanogenerator in the biomedical field is a hot field of wearable and implantable applications at present.Tumor Treating Fields(TTFields)is not only the forefront of cancer treatment research,but also has been included in treatment guidelines and applied in clinical practice in multiple countries.In this dissertation,the output of the friction nanogenerator is applied to the tumor electric field treatment,and the output signal of the friction nanogenerator directly drives the tumor electric field treatment.The research mainly focused on the following aspects:1.Two typical types of tumor electric field treatment electrodes based on friction nanogenerator are studied,and the electric field distribution of parallel plate capacitor and parallel wire electrode is theoretically studied.According to the basic theory of electromagnetism,the basic models of nanogenerator and electrostatic field distribution are studied,including piezoelectric nanogenerator,friction nanogenerator and piezoelectric friction electric hybrid power generation devices.2.The simulation model of parallel plate and parallel line electrode of tumor electric field treatment electrode based on friction nanogenerator was established,and the influence of the distance between parallel plate and parallel line,different potential difference on the distribution intensity and uniformity of electric field was studied.The arc electrode on the porous cell plate used for tumor cell research was also studied,taking the 24 hole cell plate as an example,the simulation was carried out,The simulation results are provided for the preparation of porous cell plate electric field regulation experiment.3.On the basis of the theory and simulation results,a 24 hole cell plate for electric field regulation was designed and used for the research of friction nanogenerator tumor cell electric field therapy.In addition,the application of friction nanogenerator in tumor electric field therapy was studied from the in vivo and in vitro experiments of tumor cells,and the future research was prospected.