Evaluation Of The Therapeutic Effects Of Seven Antibacterial Drugs On Natural Infection Of Coccidia In Hu Sheep

Sheep coccidiosis is a parasitic disease caused by Eimeria,which parasitizes the intestinal tract of sheep.The rate of infection and morbidity is high,and the main clinical symptoms are loss of appetite,diarrhoea,dehydration,and growth retardation,which can lead to death in severe cases.With the development of large-scale sheep farms and the improvement of people’s awareness of diseases,the harm of lamb coccidiosis to production has been paid more and more attention in recent years.The clinical control of the disease is mainly based on the combined use of sanitary measures and chemical anticoccidiosis drugs,but relevant scientific research institutions and practitioners have little research on the chemical drugs of sheep coccidiosis.The chemical drugs issued in the Chinese Veterinary Pharmacopoeia for the treatment of coccidiosis are mainly chickens and rabbits.In order to study the therapeutic effects of seven common anticoccidioid chemicals on naturally infected Huhu sheep and their effects on intestinal microflora of lambs,so as to screen out the most suitable drugs and medication procedures for clinical practice,this experiment was arranged in order to provide clinical reference and data support.1.Diagnosis of new female lamb’s coccidiosis in a breeding farmA severe coccidiosis outbreak occurred on a large-scale sheep farm in 2021 and was confirmed through field investigation,autopsy of infected sheep and laboratory examination.The sick sheep were isolated and treated,and the sheep sheds were fully disinfected.The OPG values of coccidium oocysts before and after the treatment were compared through comprehensive control measures such as oral Diclazuril,intramuscular injection of sulfadiazine sodium combined with fluid rehydration,and a good therapeutic effect was obtained,which provided a practical reference scheme for breeding enterprises to prevent and control this disease.2.Repellent effect of seven anticoccidiosis drugs on naturally infected Huhu sheep and their effects on weight gain of weaned lambsIn order to understand the treatment effect of common anticoccidiosis chemicals on lambs,48 weaner lambs naturally infected with coccidiosis were selected to evaluate the deworming effect of Diclazuril,Sulfaquinoxaline,Sodium sulfamonomethoxine,Sulfachloropyrazine sodium,Decoquinate,Monensin and Sulfamethoxazole.Fecal and rectal samples were collected on the 0d,7th,14 th,21st,28 th and 42 nd days,respectively,and the OPG value of coccidioides oocysts was counted by Mc Master counting method.The average daily gain,average weight gain rate and relative weight gain rate of sheep were measured at four times on the 0,7,28 and 42 days,respectively.The therapeutic effect of seven anti-coccidiac drugs on Hu sheep naturally infected with coccidia showed that all seven drugs could effectively kill coccidia oocysts,but the peak period and duration of action of each drug were different.Compared with other groups,the action time was longer and the anti-coccidia effect was better,which provided a reference for clinical drug use.The results showed that the weight gain of lambs in each experimental stage was different.During the whole experimental period,compared with the control group,weight gain in all groups except the sulfamethoxazole group and the Decoquinate group was higher than that in the control group,among which Sulfachloropyrazine sodium and Sulfaquinoxaline sodium had the most obvious effect on lamb weight gain.3.Effects of seven anticoccidioid drugs on intestinal floraThe use of antibiotic coccidioides often causes changes in the intestinal flora of animals.The change of intestinal flora will affect the growth of lambs to a certain extent,thus affecting the economic benefits.On the 7th day of the experiment(at the end of administration),except for Monensin group,all the other groups of the 7antibiotic groups decreased the richness and diversity of intestinal flora of Hu sheep(P>0.05),and the abundance and diversity of intestinal flora were lower in Sulfaquinoxaline Sodium group and Decoquinate group.On the 28 th day of the experiment,the intestinal microflora of each treated group recovered to a level similar to that of the untreated control group(P>0.05).The results showed that the intestinal flora of lambs gradually recovered to the normal level.As mentioned in the review,the above research results evaluated the effectiveness of seven drugs on the natural infection of coccidia in Hu sheep from the aspects of repellency,weight gain,and gut microbiota,providing data support for further screening efficient anti coccidia drugs and developing reasonable prevention and control plans for sheep coccidiosis.