Retrospective Analysis Of 171 Cases With Pancreatic Neoplasms

Objective:To analyze of clinical and pathological features of pancreatic neoplasms,especially tumor site,texture,necrosis,boundary,invasion of peripheral tissues,invasion of peripheral organs,distant metastasis,lymph node enlargement,fasting blood glucose,BMI,tumor size and CA199.Methods:The clinical data of 171 patients with pancreatic neoplasms who underwent surgical treatment in the First Affiliated Hospital of Guangxi Medical University from September 2012 to September 2018 were retrospectively analyzed.Results:The most common type of pancreatic neoplasms was pancreatic ductal adenocarcinoma,and the most common site was the pancreatic head.Among 171 patients with pancreatic neoplasms,the duodenum was the most easily invaded peripheral organ in 42 cases,accounting for 24.56%of all tumors;there was only 3 cases with splenic invasion that ranked the least,accounting for 1.75 o%f all tumors.Among distant metastases,lymph node metastasis was the most in 37 cases,accounting for 21.64%of all tumors,while the number of diaphragm metastasis was the least in 7 cases,accounting for 4.09%of all tumors.Compared with neuroendocrine carcinomas(mean age for 49.17±6.432),neuroendocrine tumors(mean age for 43.00±13.655)and solid pseudopapillary tumor(mean age for 34.67±14.08),the age of patients with tubular adenocarcinomas was older,and the difference was statistically significant(P<0.05).the age of patients with intraductal neoplasms,(mean age for 53.00±14.31),neuroendocrine carcinomas,and others(mean age for 59.17± 16.35)were older than that of patients with solid pseudopapillary tumor,and the difference was statistically significant(P<0.05).the onset age of solid pseudopapillary tumor was the youngest(mean age for 34.67±14.08)and the onset age of ductal adenocarcinoma was the oldest(60.92±11.65).The main manifestations of pancreatic ductal adenocarcinoma showed the hard texture,accounting for 86.0%of all tumors,while the manifestation of soft texture was the least,accounting for 0.0%of all tumors;intraductal neoplasms were mainly characterized by tough texture,accounting for 86.0%of all tumors,and the hard texture accounted for 1.6%of all tumors;the main manifestations of neuroendocrine carcinomas and solid pseudopapillary tumor showed the soft texture,accounting for,accounting for 20%of all tumors,and the hard texture accounted for 2.3%and 0.8%,respectively;the majority of ductal adenocarcinomas showed CA199≥ 1000U/ml with 35.9%,accounting for 95.9%of all types.The majority of neuroendocrine tumors were CA199 ≤37.0 U/ml with 100.0%,accounting for 15.4%of all types.Conclusion:The most common type of pancreatic neoplasms is pancreatic ductal adenocarcinoma,and the most common site is the pancreatic head.The onset age of solid pseudopapillary tumors is younger,while the onset age of ductal adenocarcinomas is older.The texture of pancreatic ductal adenocarcinoma is harder than that of intraductal neoplasms,neuroendocrine carcinomas and solid pseudopapillary tumor.In addition,the expression of CA199 in pancreatic ductal adenocarcinoma is high,and most of neuroendocrine carcinomas are normal.