The Clinical Effect Of Lianshi Jianpi Decoction On Impaired Glucose Tolerance Of Spleen Deficiency And Failure And Its Effect On Visfatin And Chemerin

ObjectiveTo observe the clinical effect of Lianshi Jianpi Decoction on impaired glucose tolerance in patients with spleen deficiency syndrome,and its effect on Visfatin and Chemerin,evaluates the clinical value of Lianshi Jianpi Decoction,and explore the mechanism of its effect on glucose and lipid metabolism.MethodA total of 72 patients who met the inclusion criteria were selected from the Department of Endocrinology,people’s Hospital affiliated to Fujian University of traditional Chinese Medicine from 2020.09 to 2021.10.The patients were randomly divided into control group(n= 36)and experimental group(n = 36)by SPSS.The two groups were given corresponding health education,life style guidance and nutritional treatment plan,the breakfast of the control group was steamed bread made of 1 egg + 50 g raw flour,and the breakfast of the experimental group was 1 egg + 50 g Lianshi Jianpi Decoction.The treatment period of both groups was 90 days.The changes of TCM syndrome score,blood glucose,blood lipid,Visfatin,Chemerin,body mass index,body fat rate,visceral fat area and waist circumference were observed in the two groups before and after treatment.Results1.There was no significant difference in sex,age,TCM syndrome score and laboratory examination between the two groups(P>0.05).2.The levels of Visfatin and Chemerin in the subjects in this study were different from those in the healthy control group(P < 0.05).3.The score of TCM syndrome in the two groups decreased after treatment(P < 0.01),and the curative effect of the experimental group was better than that of the control group(P <0.05).4.Compared with VF and CHEM,VF and CHEM in the experimental group decreased after treatment(P < 0.05);The curative effect of the experimental group was better than that of the control group on VF(P < 0.05),and the curative effect of the two groups on CHEM was the same(P > 0.05).5.Compared with the indexes of glucose metabolism,the blood glucose at 2h after meal in the experimental group was lower than that in the previous group(P < 0.01),and the curative effect of the experimental group was better than that of the control group(P < 0.01).There was no significant difference in fasting blood glucose and Hb A1 c within and between groups(P > 0.05).6.In the comparison of lipid metabolism indexes,there was no statistical significance in the test group before and after TC treatment,and the TC in the control group increased after treatment(P < 0.05);Compared with the difference between groups,the curative effect of TC in the experimental group was better than that in the control group(P < 0.05).There was no significant difference in TG and LDL-C within and between groups(P > 0.05).7.The waist circumference,BMI,body fat rate and visceral fat area of the experimental group decreased after treatment(P < 0.01);The waist circumference and BMI of the control group decreased after treatment(P < 0.05),and there was no significant difference in body fat rate and visceral fat area before and after treatment(P > 0.05).The body fat rate of the experimental group was better than that of the control group(P < 0.05);BMI,waist circumference and visceral fat area were equivalent(P > 0.05)8.During the clinical trial,the safety indexes of all patients were within the normal range,and there were no adverse events such as hypoglycemia,abnormal liver and kidney function,gastrointestinal discomfort,allergic reaction and so on.Conclusion1.Lianshi Jianpi Decoction combined with lifestyle intervention can alleviate the cl inical symptoms of traditional Chinese medicine.2.Lianshi Jianpi Decoction can improve glucose and lipid metabolism,and reduce glu-cose by reducing the accumulation of fat cells and insulin resistance.3.In this study,there was no adverse reaction in the treatment process,and Lian shi Jianpi Decoction was safe.