Preparation Of Long-wavelength Light-responsive Biomaterials And Their Applications In Muscle Injury And Antibacterial Coatings

This series of work focused on the preparation of long-wavelength light-responsive biomaterials,their physicochemical properties,biocompatibility and applications in the field of muscle injury and antibacterial coatings.The main contents of this paper were as follows:(1)This section briefly introduced the research background and applications in biomedical field of the following subjects: light-responsive biomaterials,microneedle(MN)drug delivery system and zinc oxide(Zn O).Afterward,the basis of the topic of this paper was put forward.(2)In this section,we aimed to achieve the efficient repair of damaged skeletal muscle using polyvinyl alcohol soluble MN patches loaded with carbonized wormwood(CW)and prostaglandin E2(PGE2).The introduction of CW imparted the MN with near-infrared(NIR)light heating characteristics that improved the efficiency of PGE2 delivery in the damaged muscle area.The corresponding experimental results showed that compared with classical moxibustion treatment,the system could more quickly restore muscle strength and the cross-sectional area of muscle bundle fibers,and thus effectively repairing the damaged skeletal muscle in a mouse model of muscle injury.Above all,this light-controlled photothermal MN drug delivery system avoided the common problems of traditional moxibustion such as large levels of smoke,slow efficacy and risk of scalding,which produced a safe,accurate and efficient approach for the treatment of muscle injury.(3)The circulation of banknotes is frequent and complex.When banknotes are exposed to humid and unclean situations,usually there are a large number of bacterial adhesions on the surface of banknotes,which is the source of various types of infections.In this section,we prepared a multi-functional coating of banknotes with superior antibacterial and antifouling properties through combining a dual-property Zn O(D-Zn O)constructed composite with special hydrophobic ultraviolet gloss oil,in which D-Zn O was based on hydrophilic Zn O(H-Zn O)and porous Zn O(P-Zn O).Apart from its regular antibacterial capacity,the antibacterial performance could be further promoted in the humid environment.More importantly,the D-Zn O coating could respond to dual-light including yellow light(YL: 560 nm)and ultraviolet light(UV: 365 nm).The non-destructive removal of bacterial biofilms on the surface of banknotes could be achieved by a healthy and facile YL irradiation used in daily life;the D-Zn O coating could also emit yellow fluorescence as an anti-counterfeiting label of banknotes under short wavelength of UV irradiation.