Evaluation Value Of Preoperative Serum Transaminase Ratio Combined With Serum Tumor Markers For Prognosis Of Patients With Stage Ⅲ Colorectal Cancer

Objective:To investigate the prognostic value of the ratio of preoperative serum alanine aminotransferase and aspartate aminotransferase(LSR)combined with preoperative serum tumor markers(TM)in patients with stage III colorectal cancer(CRC).Methods:The clinical data of 209 CRC patients with stage Ⅲ postoperative pathological results surgically treated in the Department of Gastrointestinal Surgery of the Second Affiliated Hospital of Nanchang University and the General Surgery Department of the First Affiliated Hospital of Nanchang University from August 2017 to December2018 were retrospectively analyzed,and the laboratory data were collected.The primary follow-up outcomes were 3-year disease-free survival(DFS)and 3-year overall survival(OS).Survival analysis was conducted with the Kaplan–Meier method,and Cox regression analysis was used to determine significant independent prognostic factors for predicting survival.Rank sum tests are used to compare categorical variables.A p value of <0.05 was considered to be statistically significant.Result:Between August 2017 and December 2018,a total of 209 patients were enrolled in the two hospitals,including 115 males and 94 females.Multivariate analysis showed that the independent prognostic factors for 3-year disease-free survival of stage Ⅲ colorectal cancer were LSR(HR: 0.47;95% CI: 0.32 0.70;p< 0.001)and CEA(HR:1.72,95%CI:1.16-2.55,p=0.007).Independent prognostic factors for3-year overall survival of stage Ⅲ colorectal cancer were LSR(HR: 0.57;95% CI:0.36 0.910;p=0.02)and CA199(HR:1.69,95%CI:1.05-2.71,p=0.029).Kaplan-Meier survival curve showed that LSR combined with TM could evaluate the 3-year DFS and 3-year OS of stage Ⅲ colorectal cancer(DFS: p <0.001;OS: p=0.026).Conclusion:1.Patients with high perioperative preoperative serum transaminase ratio and low serum CEA、CA199 had a better prognosis than other stage Ⅲ colorectal cancer patients.2.Perioperative preoperative serum transaminase ratio combined with CEA、CA199 has certain reference in the prognosis assessment of patients with stage Ⅲcolorectal cancer.