| Objective: The vaginal microecology and cervical function indicators were measured to compare the changes in vaginal microenvironment and cervical function in preoperative and postoperative HSIL patients of childbearing age,to explore the effects of different conization methods(LEEP,CKC)on the recovery of vaginal microecology and cervical function in HSIL patients of childbearing age,and to evaluate the recovery of vaginal microecology and cervical function in HSIL patients after conization.Provide a theoretical basis for guiding women of childbearing age who have fertility requirements after conization to choose the appropriate postoperative pregnancy timing.Methods:(1)54 Women of childbearing age who were diagnosed with HSIL and underwent conization in the Affiliated Hospital of Guilin Medical University from October 2020 to July 2021 were selected as the observation group,of which41 postoperative 3 months patients and 31 postoperative 6 months patients were collected;selected 54 normal healthy women of childbearing age as the control group at the same time.To measure the vaginal secretion microecological detection and indicators related to the risk of pregnancy infection including vaginal p H,vaginal cleanliness,leukocyte esterase,BV screening and the transvaginal ultrasonography measurement indicators including cervical length,width,thickness,shape and cervical elasticity value in the preoperative group,postoperative 3 months group,postoperative 6 months group and the control group.The method of group control was used to compare and analyze the differences in vaginal secretion microecological detection indicators and cervical function measurement indicators between different groups,and to explore the effects of different conization methods on the recovery of vaginal microecology and cervical function in HSIL patients of childbearing age,and to evaluate the recovery of vaginal microecology and cervical function in HSIL patients after conization.(2)Statistical methods: SPSS 22.0 statistical software was applied for statistical analysis of the data.The data in the measurement data that conformed to the normal distribution were compared by matched samples t-test or independent samples t-test,and the data that did not conform to the normal distribution were compared by nonparametric tests.The count data were compared by Pearson’s chi-squared test,Mc Nemar’s test or Fisher’s precision probability test.As P<0.05 was set to indicate a statistically significant difference.Results:(1)Comparative analysis of the vaginal microecology and cervical function between the control group and the preoperative group: in the preoperative group,the vaginal microecology in the percentage of vaginal cleanliness grade III and above and the percentage of vaginal PH>4.6 was significantly higher.Compared with the control group,the difference was statistically significant(P<0.05).There was no statistically significant difference in the cervical function indexes between the preoperative group and the control group(P>0.05).(2)Comparative analysis of the vaginal microecology and cervical function between the control group and the postoperative group: there was no statistically significant difference in the vaginal microecology and cervical function indexes between the control group and the postoperative group(P>0.05).(3)Comparative analysis of the vaginal microecology and cervical function between the preoperative group and the postoperative group: the proportion of vaginal PH ≤ 4.6 in the vaginal microecology in the postoperative group was significantly higher.Compared with the preoperative group,the difference was statistically significant(P<0.05).There was no statistically significant difference in the cervical function indexes between the preoperative group and the postoperative group(P>0.05).(4)Comparative analysis of the vaginal microecology and cervical function between the postoperative 3 months group and the postoperative 6 months group: there was no statistically significant difference in the vaginal microecology and cervical function indexes between the postoperative 3 months group and the postoperative6 months group(P>0.05).(5)Comparative analysis of different conization methods on the recovery of vaginal microecology and cervical function in the postoperative 3 months group: the cervical length of the LEEP group was significantly longer.Compared with the CKC group,the difference was statistically significant(P<0.05).There was no statistically significant difference in the cervical function indexes between the LEEP group and the CKC group(P>0.05).(6)Comparative analysis of different conization methods on the recovery of vaginal microecology and cervical function in the postoperative 6months group: the cervical length of the LEEP group was significantly longer.Compared with the CKC group,the difference was statistically significant(P<0.05).There was no statistically significant difference in the cervical function indexes between the LEEP group and the CKC group(P>0.05).Conclusion:(1)At 3 months and 6 months after conization,patients with HSIL who underwent LEEP had a better recovery of cervical function after conization than those who underwent CKC.(2)The recovery of vaginal microecology and cervical function in HSIL patients at 3 months after conization is close to that of normal healthy women,suggesting that patients with strong pregnancy requirements,older age,declining ovarian function,good compliance,fully informed and voluntary risk-taking can consider preparing for pregnancy in 3months after conization. |
