Clinical Efficacy And Safety On Early Enteral Nutrition Support Treatment In Severe Acute Pancreatitis

Objective: To investigate the clinical efficacy and safety of early enteral nutrition(EN)support in the treatment of severe acute pancreatitis(SAP).Methods: A retrospective study was conducted on 110 patients who met the diagnostic criteria of SAP and received early nutritional support treatment in our hospital from January2018 to April 2022.They were divided into groups according to their condition needs and patients’ wishes for nutritional support.There were 54 cases in EEN group(receiving enteral nutrition support 48 hours after admission)and 56 cases in total parenteral nutrition(TPN)group(receiving routine treatment and total parenteral nutrition support).Analysis of two groups of patients with clinical observation index(bowel movement,through the mouth eating bowel sounds recovery time,abdominal pain relief time)and the experimental values associated with disease(blood amylase,urine amylase,neutrophils,hypersensitive c-reactive protein and calcitonin original recovery time)and the hospitalization time of two groups of patients,organ damage,mortality,The clinical efficacy and safety of the two groups were evaluated comprehensively.Results: The recovery time of blood amylase,urine amylase,bowel sounds,defecation,abdominal pain relief,oral feeding and hospital stay in the EEN group were better than those in the TPN group(blood amylase 3.2±1.1 days,urinary amylase 5.2±1.5 days,bowel sounds3.5±1.1 days,defecation 4.7±1.4 days,and abdominal pain relief 3.5±1 days in the EEN group.The recovery time of blood amylase 4.1±0.9 days,urine amylase 6.5±1.6 days,bowel sound 4.4±1.0 days,defecation 6.2±1.4 days,abdominal pain relief 4.7±1.1 days,oral eating8.2±1.6 days,hospitalization 10.2±3.4 days were shorter than those of TPN middle group 13.3±4.2 days,P <0.05);Neutrophilic granulocyte(NE),high sensitivity C reactive protein(CRP),procalcitonin(PCT)and other recovery times were shorter than those of TPN group(NE3.6±1.5 days,CRP3.7±1.4 days,PCT3.7±1.4 days in EEN group were shorter than those of NE4.8±1.5 days,CRP5.1±1.6 days,PCT5.1±1.6 days in TPN group,P <0.05);The incidence of complications in EEN group was 16.67% lower than that in TPN group 42.86%(P=0.0027,P <0.05),and there was no significant difference between the two cases of death in EEN group(3.70%)and the four cases of death in TPN group(7.14%)(P=0.427,P >0.05).The total effective rate of EEN group was 83.33% significantly higher than that of TPN group(57.14%,P=0.0027,P <0.05).Conclusion:(1)EEN support therapy for SAP can accelerate the recovery of various clinical and laboratory indicators of patients.(2)EEN can shorten the length of hospital stay and improve the clinical efficacy.(3)EEN can reduce the incidence of complications and is safe to use.