Correlation Between Visceral Fat Area And Carotid Intima-media Thickness In Newly Diagnosed Type 2 Diabetes Patients

Objective: The purpose of this study was to investigate the relationship between visceral fat area in a population with primary diagnosis of Type 2 Diabetes(T2DM)and carotid artery intima-media thickness,to further observe the effect of visceral fat on the risk of atherosclerosis.The study was conducted to investigate the optimal threshold value of visceral fat area for predicting atherosclerosis in T2 DM patients,and to provide assistance for future clinical prevention and treatment.Methods: A total of 501 patients with T2 DM diagnosed by the Metabolic Disease Management Center(MMC)of Changde First People’s Hospital between 2020.5 and2021.10 were selected.General clinical data were collected,such as gender,age,height,weight,smoking status,systolic blood pressure,and systolic blood pressure.General clinical data such as gender,age,height,weight,smoking status,systolic blood pressure(SBP),diastolic blood pressure(DBP),etc.were collected.Biochemical parameters included glycated hemoglobin(Hb A1c),fasting blood glucose(FPC),2-hour postprandial glucose(2h PG),fasting C-peptide(FCP),2-hour postprandial C-peptide(2h CP),Fasting serum insulin(FINS),2h postprandial insulin(2h INS),alanine aminotransferase(ALT),aspartate aminotransferase(AST),serum sarcoplasmic ratios(Scr),blood urea nitrogen(BUN),and uric acid(UA),triglycerides(TG),high-density lipoprotein(HDL-C),Total cholesterol(TC).Low density lipoprotein(LDL-C).The insulin resistance index(HOMA-IR),insulin secretion index(HOMA-B),and body mass index(BMI)were calculated.Brachial-ankle pulse wave velocity(ba PWV)and ankle-brachial index(ABI)were measured using arteriosclerosis.Carotid artery intima-media thickness was measured using ultrasonography.Visceral fat area(VFA)and subcutaneous fat area(SFA)were measured using bioresistance.Statistical treatment: SPSS 22.0 statistical software was used to Statistical software was used to organize and analyze the data,and the difference was considered statistically significant at P<0.05.Results :1.A total of 501 subjects were included in this study,including 304 men,197women(73 premenopausal women,and 124 postmenopausal women).Compared with men,premenopausal and postmenopausal women had lower weight,VFA waist circumference,SCr,UA were lower.and higher HDL-C: the differences were statistically significant(all P<0.05).The age SBP of postmenopausal women was given BUN,Scr,HDL-C,ABI,ba PWV,CIMT were higher than premenopausal women,while weight,BMI,hip circumference,UA were lower than premenopausal women.There have been statistically significant differences(P<0.05).2.The VFA in the CIMT thickened group was significantly higher than that in the normal group(all P<0.001),and compared with the normal group,The levels of age,SBP,DBP,weight,BMI,SFA,hip circumference and waist circumference were significantly higher in the CIMT thickened group compared with the normal group.The difference was statistically significant(P<0.05),and the HOMA-B level in the normal group was higher than that in the thickened group(P<0.05).3.Spearman correlation analysis showed that VFA and BMI,CIMT,SBP,DBP,body weight,SFA,hip circumference,waist circumference,ALT,AST,Scr,UA,TG,LDL-C,FINS,FCP,2h CP,Hb AIc,HOMA-IR,urine-protein/liver-muscle,Urine-microalbu min,HOMA-B,FBG,2h PG were positively correlated,and negatively correlated with HDL-C(P<0.05).CIMT was associated with age,BMI,VFA,SBP,body-weight,SFA,hipcircumference,waist-circumference,FINS,HO MA-IR,Urine-protein/creatinine,2h PG,ba PWV(P<0.05).4.A linear relationship between VFA and CIMT was observed in the smoothed curve fitting,and as VFA increased,the risk of CIMT the risk of developing thickening gradually increased.Multiple linear regression with CIMT as dependent variable adjusted for age,sex,smoking history,SBP,DBP,SFA,VFA,BMI,hip circumference,waist circumference,TG,LDL-C,TC,HDL-C,Post-analysis of influencing factors such as shows that VFA is still an independent influencing factor of CIMT5.From the ROC curve analysis,the area under the curve of ROC values for the critical value of VFA predicting CIMT in T2 DM was 0.672(95% CI 0.622-0.722,P<0.001)and the best cut-off value for VFA was 97.45 cm2(sensitivity.69.2%,specificity: 60.2%)Conclusion:VFA is an independent risk factor for CIMT in patients with primary diagnosis of T2 DM mellitus.VFA≥100cm2 can effectively identify carotid atherosclerosis in Chinese population.