| ObjectiveAnalyze the expression of D2-40 and ISG-15 in papillary thyroid carcinoma and nodular goiter,and analyze the correlation between the expression of D2-40 and ISG15 in lymph nodes of papillary thyroid carcinoma,providing valuable experimental data for clinical diagnosis and treatment of papillary thyroid carcinoma and prediction of patients’ condition.MethodsThis study was selected from the clinicopathologic information of 69 thyroid cancer patients,and these patients received surgical treatment and treatment at the first hospital of kwanan Medical University / Katsuyama kurasu hospital from January2016 to December 2022.In these cases,there were 13 males and 56 females.All patients who have been elected have not received chemotherapy or radiation therapy before surgery.The papillary thyroid carcinoma with or without lymph node metastasis was examined using the SP immunohistochemical method and its pathological change was determined.We analyzed the density of lymph vessels in tumor lesions,and analyzed the correlation between ISG15 and D2-40 expression and PTC prognosis in lymph node metastasis.Statistical analysis of data using SPSS 25.Results1.There are 13-males and 56-females with PTC;The age range is 22–79years,with the average age being about 45.94 years old and the median 35 years old.There is no significant age difference between the sexes(t=0.268,P>0.05);Most patients came to the doctor to find painless neck mass that moved up and down as they swallowed.2.In the cervical lymph node metastases group,the expression level of d2-40 was significantly higher than in the cervical lymph node metastases group,and MLVD values were 14,95 ± 7,05 respectively.9.95 ± 4.22,with a statistically significant difference(P<0.05).3.There was no statistically significant difference in the expression of d2,40(P>0,05)in different age and gender groups of thyroid cancer.4.The expression level of ISG15 in the cervical lymph node metastases group(t=6.268,P>0.05)was significantly higher than in the cervical lymph node metastases group(t=2.148,P>0.05),and the difference was statistically significant(P<0.05).5.There was no statistical difference in the expression of ISG15 between different sex groups(P>0.05)in patients with thyroid cancer.6.All PTC cases have been surgically removed;Among them,15-cases recurred within a year of surgery,and recurrent patients were accompanied by lymph node metastases.Conclusion1.The sex of PTC disease is more female than male.It occurs before the age of 50,and more people have symptoms.Most patients can be diagnosed as painless cervical plaques,which move up and down when swallowing.Most patients can be diagnosed by imaging,and atypical cases need standard pathological diagnosis.There is no significant difference between the age distribution or gender of patients with papillary thyroid carcinoma with or without lymph node metastasis,indicating that the presence or absence of lymph node metastasis may be unrelated to the age and gender of patients.3.The expression level of D-40 in PTC tissue was significantly correlated with cervical lymph node metastasis.Therefore,it can be inferred that it plays a role in lymph node metastasis in thyroid papillary carcinoma and can be used as an important reference index to evaluate whether cervical lymph node metastasis occurs in patients with thyroid papillary carcinoma.4.The expression level of ISG15 in PTC tissue was significantly correlated with cervical lymph node metastasis.It can be considered to participate in the process of cervical lymph node metastasis of papillary thyroid cancer,and can be used as a reference index to evaluate the cervical metastasis of patients with papillary thyroid cancer.5.The expression of D2-40 labeled MLVD in PTC tissue was positively correlated with the expression of ISG15,indicating that ISG15 might be related to the lymphatic metastasis of PTC.The two indicators can improve the accuracy of PTC ganglion metastasis.6.Among the 69 patients examined within one year after surgery,15 patients recurred,and all patients with recurrence were accompanied by lymph node metastasis.Implicit recurrence may be related to lymph node metastasis. |
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