Study On The Correlation Between Systemic Immune-Inflammation Index And Post-Stroke Depression In Acute Stage Of Ischemic Stroke

ObjectiveTo explore the correlation between venous blood SII and Post-stroke depression(PSD)in patients with acute ischemic stroke.MethodsPatients diagnosed with acute cerebral infarction admitted to neurology ward from January 2021 to May 2022 in Wafangdian Third Hospitalwere included.Patients’ age at admission,occupation,past medical history,imaging data,venous blood routine results,and the evaluation of the degree of depression on the Hamilton Depression Scale(HAMD-24)at follow-up 1 month later were recorded by multiple logistic regression analysis,and the correlation between PSD and SII calculated by venous blood routine at admission in patients with ischemic stroke was discussed.SPSS 25.0 was used for statistical analysis.ResultsPatients with PSD had higher SII,d NLR,NLR,PLR than patients without PSD,respectively.Patients with acute ischemic stroke showing high SII,d NLR,PLR,NLR were more likely to develop PSD,especially high SII after adjusting for confounders.The SII was a better indicator of risk of the development of PSD compared with d NLR,NLR,PLR.94(30.3%)of acute ischemic stroke patients were diagnosed as depression 1 month later.In addition,the results showed that the functional prognosis of PSD patients is poor,and the stroke is more serious.ConclusionsThis study primarily demonstrated that higher SII was independently associated with a higher risk of developing PSD.To diagnose and treat PSD,monitor its change over time,and follow up PLR,d NLR,and NLR regularly.Increased levels of SII,d NLR,NLR,and PLR were associated with increased prevalence of PSD.Therefore,immunoinflammatory markers can be used not only as biomarkers for ischemic stroke and post-stroke depression,but also to assess systemic inflammatory status and prognostic risk in post-stroke patients.