Clinical Observation And Immune Status Of Children With Henoch-Sch(?)nlein Purpura

Objective: To statistically analyze the clinical application,efficacy and immune status of the 2020 version of the Chinese Medicine Diagnosis and Treatment Plan for Children’s Henoch-Sch?nlein Purpura(hereinafter referred to as the "Plan")of the Affiliated Hospital of Shandong University of Traditional Chinese Medicine.Methods: A retrospective study was conducted to collect 174 hospitalized cases of Henoch-Sch?nlein Purpura who met the inclusion criteria in the Department of Pediatrics.Affiliated Hospital of Shandong University of Traditional Chinese Medicine from January 2020 to December 2021.The diagnosis,syndrome differentiation,prescription medication and syndrome score were statistically analyzed,and the application and efficacy of the protocol were analyzed and evaluated.The immune index data of 103 children with complete immune index data were statistically analyzed.Results:1.A total of 174 children with Henoch-Sch?nlein Purpura were included in this study.Males were more than females,and children of pre-school age and school age were more common.Respiratory tract infection was the most common cause,influenza B virus,Mycoplasma pneumoniae and Streptococcus were common pathogens,and renal type accounted for about 20.1% of the children with clinical classification.2.According to the "Plan",the consistency of TCM syndrome differentiation type was 100%,and the total consistency of clinical prescriptions was 97.7%,among which Guizhi Fuling Pill and Taohe Chengqi Decoction were 4 prescriptions outside the "Plan".After referring to the "protocol" treatment,the clinical recovery rate was24.14%,the significant efficiency was 56.32%,the effective rate was 17.82%,and the total effective rate was 98.28%.3.The percentage of T inhibitory toxic cells,total B cells and absolute value in children with Henoch-Sch?nlein Purpura were higher than those in healthy children,and the differences were statistically significant(P < 0.01).The total T cell percentage,total B cell percentage and absolute value of children with renal type were higher than those without renal type,and the differences were statistically significant(P < 0.01).The percentage of T inhibitory toxic cells in children with renal type was higher than that in children without renal type,and the difference was statistically significant(P <0.05).Conclusion:1.The clinical application of the Scheme is in good condition.It is suggested that Guizhi Fuling Pill and Taohe Chengqi Decoction should be added to the recommended prescriptions for Qi stagnation and blood stasis syndrome in the Scheme to enrich and improve the Scheme.2.Children with Henoch-Sch?nlein Purpura have abnormal humoral and cellular immunity,in which T and B cells may participate in the process of renal damage.