Study On The Correlation Between TCM Syndrome Types Of Chronic Heart Failure And Adipokine Asprosin

Objective: By detecting the plasma level of Asprosin in patients with chronic heart failure(CHF),collecting the levels of N-terminal proBtype natriuretic peptide(NT-proBNP)and left ventricular ejection fraction(LVEF),this paper discusses the correlation between adipokine Asprosin and TCM syndrome types and cardiac function classification(NYHA)of CHF,in order to provide new ideas and methods for clinical diagnosis and treatment of CHF,and provide objective reference for TCM syndrome differentiation and classification.Methods: 90 CHF patients and 30 healthy people who met the diagnostic criteria,inclusion criteria and exclusion criteria were selected.According to NYHA cardiac function grading standard,90 patients with CHF were evaluated and graded,and divided into three groups: Ⅱ,Ⅲ and Ⅳcardiac function.According to the symptoms,signs,tongue and pulse of patients,TCM syndrome differentiation is divided into three groups: qi deficiency and blood stasis syndrome,qi and yin deficiency and blood stasis syndrome,and yang deficiency and blood stasis syndrome.Plasma Asprosin level was detected,NT-proBNP and other laboratory tests were collected,and LVEF was collected by color Doppler echocardiography.The data analysis was completed by SPSS27.0,and all of them were P<0.05,indicating that the difference was statistically significant.Results:(1)There was no statistical difference in the gender composition and age distribution between CHF patients with different cardiac function grades and healthy controls(P>0.05).(2)Compared with the healthy control group,there were no statistical differences in ALT,AST,LDL-C,Lp(a),FBG and Hb A1 c in CHF groups with different cardiac function grades(P>0.05).BUN,Scr,TG,TC,HDL-C were significantly different from those in the control group(P<0.05),and BUN and Scr were significantly higher in the group of cardiac function Ⅲand Ⅳ than that in the group of cardiac function Ⅱ(P<0.05).(3)Compared with the healthy control group,the levels of Asprosin and NT-proBNP in CHF groups with different cardiac function grades were significantly different(P<0.05),and there were statistical differences among the groups(P < 0.05),which gradually increased with the deterioration of cardiac function,showing that the healthy control group<cardiac function Ⅱ<cardiac function Ⅲ<cardiac function Ⅳ.Compared with the control group,LVEF in the cardiac function Ⅲ and Ⅳ groups had statistical differences(P < 0.05),and the order was healthy control group>cardiac function Ⅱ>cardiac function Ⅲ>cardiac function Ⅳ.(4)There is no statistical difference in the gender composition and age distribution between different TCM syndrome groups of CHF and healthy control group(P>0.05).(5)Compared with the healthy control group,there was no statistical difference in ALT,AST,TG,LDL-C,Lp(a),FBG and Hb A1 c among TCM syndrome groups of CHF(P > 0.05).The differences of BUN,Scr,TC and HDL-C in different TCM syndrome types of CHF were statistically significant compared with those in the control group(P<0.05),and BUN and Scr were significantly higher in the group of Yang deficiency and blood stasis(P<0.05).(6)Compared with the healthy control group,the plasma levels of Asprosin and NT-proBNP in CHF TCM syndrome groups were significantly increased(P < 0.05),which gradually increased with the changes of syndrome types of qi deficiency and blood stasis → blood stasis of both qi and yin deficiency → blood stasis of yang deficiency.LVEF in different TCM syndrome groups of CHF was significantly different from that in the control group(P<0.05),and it decreased with the change of syndrome types of deficiency of qi and blood stasis → deficiency of both qi and yin → deficiency of yang and blood stasis.(7)Asprosin expression in plasma was positively correlated with NTproBNP level(r=0.642,P<0.001)and negatively correlated with LVEF(r=-0.308,P<0.001).(8)The cardiac function grading of CHF was positively correlated with the expression level of plasma Asprosin(r=0.527,P < 0.001),with the level of NT-proBNP(r=0.838,P < 0.001)and negatively correlated with LVEF(r=-0.454,P<0.001).(9)TCM syndrome types of CHF are positively correlated with plasma Asprosin expression level(r=0.350,P < 0.001),with NT-proBNP level(r=0.739,P < 0.001)and negatively correlated with LVEF(r=-0.250,P=0.018).Conclusions:(1)The plasma Asprosin level increased with the increase of NT-proBNP level and decreased with the increase of LVEF,indicating a positive correlation with the degree of heart failure.(2)The level of plasma Asprosin is positively correlated with the cardiac function classification of CHF patients.With the deterioration of cardiac function,the expression level of plasma Asprosin gradually increases.(3)The level of plasma Asprosin is positively correlated with the changes of TCM syndrome types in CHF patients,which is characterized by qi deficiency and blood stasis<qi and yin deficiency and blood stasis<yang deficiency and blood stasis.(4)Asprosin can be used as a biomarker for the diagnosis and prognosis of CHF.