Stduy On Prevention And Treatment Of Recurrent Abortion With Traditional Chinese Medicine Before Pregnancy Based On Data Mining Of Professor Xuhuijun’s Gynecology

Objective: First,to discover the possible commonalities in various clinical data of patients with a history of slippery fetuses,and second,to explore the dialectical patterns and medication characteristics of Dr.Xu in the treatment of recurrent miscarriage.Methods: A retrospective analysis was conducted from September 2020 to December 2022 at the Obstetrics and Gynecology Department Outpatient Department of Qingdao Traditional Chinese Medicine Hospital and Professor Xu Huijun of the Famous Medical Hall.200 patients who met the diagnostic criteria for recurrent miscarriage were included in the medical records,four diagnosis information forms,and traditional Chinese medicine body mass tables.Firstly,the basic information of the patient,menstrual status,overall condition,traditional Chinesemedicine syndrome differentiation and classification,traditional Chinese medicine prescriptions,and traditional Chinese medicine constitution types involved in the above information will be entered into a Microsoft Office Excel table to establish a preliminary information database.Then,standardize the description of the above information data.Finally,use appropriate statistical analysis tools for data calculation and mining,specifically for descriptive statistical analysis of data using Microsoft Excel software;Using IBM SPSS Modeler 18.0 software for data association rule analysis;Cluster analysis of datausing IBM SPSS Statistics 25.0software.Results: 1 Basic information of the patient: The average age of patients with recurrent miscarriage in this study is 33.47 years old,with a minimum age of 24 years and a maximum age of 43 years.The age of onset of the disease is concentrated between 30 and 34 years old,accounting for 50% of the total number of researchers,followed by 21% of the total population aged 35 to 39.The frequency of miscarriages is mainly concentrated in 2-3,accounting for 91% of the total number ofresearchers,and 26% of the total number belong to secondary recurrent miscarriages.2 Menstrual distribution of patients: in this study,the majorityof patients with recurrent miscarriage had normal menstruation,accounting for 57%,while patients with menstrual disorders accounted for43%.The main menstrual types of patients with menstrual disorders were low menstrual volume and late menstrual period,accounting for 19%and 12%of the total population,respectively.3 The distribution of main clinical symptoms of 3 patients: The most prominent clinical symptoms of patients in this study are menstrual blood clots(58%),low back and knee pain(42%),dysmenorrhea(39%),and breast swelling pain(39%).The more common symptoms are mental fatigue,fear of cold limbs,irritability,difficulty falling asleep,irritability,irritability,dreaminess,forgetfulness,and difficulty waking up from sleep.4 Distribution of traditional chinese medicine syndrome types of patients: in this study,the TCM syndrome types of patients are divided into nine categories,mainly including concurrent and mixed syndrome types.The top four syndrome types are: kidney deficiency and blood stasis syndrome(22.0%),liver depression and spleen deficiency syndrome(15.5%),liver and kidney yin deficiency syndrome(14.5%),and kidney qi deficiency syndrome(12%).5 Distribution of traditional chinese medicine constitution typesof patients: most of the patients in this study have biased TCM constitution,with the top three being yang deficiency(31%),qi depression(17%),and qi deficiency(15%),accounting for 63% of the overall proportion.The other constitutions are in order of yin deficiency,dampness heat,blood stasis,phlegm dampness,calmness,and innate qualities.6 Analysis of clinical drug prescriptions for the prevention and treatment of this disease by professor Xu:6.1 Common prescriptions and medicines: The most commonly used formula is Shoutai Wan,accounting for 21%.The remaining ones are Zuogui Yin combined with Xiaoying Jian,Bashu yijing Tang,Chaihu shugan San combined with Sijunzi Tang,etc.There are 15 commonly used medicines,namely: poria cocos,rehmannia glutinosa,white peony,angelicasinensis,atractylodes macrocephala,codonopsis pilosula,chuanxiong,goji berries,salt dodder seed,yam,vinegar Xiangfu,salvia miltiorrhiza,bupleurum chinense,fructus corni,and caulis spatholobi.6.2 The four qi,five flavors,and meridians of medicines: the medicinal properties are mainly concentrated in the warm,calm,slightly cold,and slightly warm categories,while the five flavors are mainly concentrated in the sweet,spicy,and bitter categories.Meridiansaremainly attributed to the three meridians of the kidney,liver,andspleen.6.3 Common drug combinations: The top three drug combinations with support are atractylodes macrocephala-codonopsis pilosula(46.82%),paeonia lactiflora-chuanxiong(38.18%),and rehmannia glutinosa-lycium barbarum(32.73%);There are three drug combinations with a confidence level of over 90%,namely gouqi-angelica sinensis-rehmannia glutinosa(94.12%),codonopsis pilosula-poria cocos-atractylodesmacrocephala(93.65%),and ligusticum chuanxiong-angelica sinensis-rehmannia glutinosa-paeonia lactiflora(90.91%).6.4 Core recipe combination: a total of 20 traditional chinese medicines,including: rehmannia glutinosa,peony bark,atractylodes macrocephala,white peony root,salt Zexie root,salt dodder seed,poriacocos,fructus corni,vinegar xiangfu,orange peel,caulis spatholobi,Ophiopogon japonicus,stir-fried fructus aurantii with bran,danshen,codonopsis pilosula,chinese yam,chuanxiong,angelica sinensis,fructus lycii,and bupleurum.6.5 Cluster combination: derived 5 new prescription combinations,namely C1: morus parasiticus-dipsacus officinalis-scutellaria baicalensis-rehmannia glutinosa-cuscuta chinensis-raspberry;C2: peony Peel-salt zexie-Yam-wine yurou-cocos-atractylodes;C3:eucommia ulmoides olive-morinda officinalis-salvia miltiorrhiza-rehmanniaglutinosa-paeonia lactiflora-gouqi-caulis spatholobi-angelica sinensis-safflower;C4: vinegar xiangfu-stir fried with bran-fructus aurantii-chuanxiong-chaihu-atractylodes macrocephala-codonopsis pilosula-Orange peel;C5: maidong-ivnegar schisandra-cinnamomi.Conclusion: the common characteristics of patients with a historyof slippery fetuses in this study are: gradually aging,mainly concentrated between the ages of 30 and 39,with the majority seeking medical attention after two miscarriages;Menstrual abnormalities are mainly manifested in low volume,late stage,or with blood clots,often accompanied by lower back and knee pain,dysmenorrhea,breast swellingand pain,and more obvious mental,emotional,and sleep disorders;The main syndrome types of traditional Chinese medicine are kidney liver spleen deficiency,combined with blood stasis;The constitution of TCM with high incidence rate is yang deficiency,qi stagnation and qideficiency.The second conclusion is that Xu Shi’s prescription selection for this disease is as follows: traditional Chinese medicine often selects sweet and warm herbs,which belong to the three meridians of liver,spleen,and kidney,with the main effects of tonifying the kidney and tonifying essence,soothing the liver and regulating qi,strengthening the spleen and qi,and nourishing blood and removing stasis.He often selects kidney tonifying drugs and blood nourishing drugs,as well as spleen tonifying and qi tonifying drugs in combination;The commonly selected formulas are Shoutai Wan,Zuogui Yin combined with Xiaoying Jian,Bashu Yijing Tang,Chaihu Shugan San combined with Sijunzi Tang;The core formula combination obtained by using complex networks is mainly composed of drugs that tonify the kidney,spleen,and liver,nourish blood,promote blood circulation,and remove blood stasis;The new prescription combination obtained through clustering,tracing analysis,and tailoring to Xu Shi’s treatment of this disease are often selected.