Meta-Analysis And Medication Rule Of Chinese Medicine In The Treatment Of Dampness-Heat Hepatitis B With Jaundice

Objective: In this study,evidence-based medicine was used to systematically evaluate the clinical efficacy of traditional Chinese medicine in the treatment of patients with dampness-heat chronic hepatitis B with jaundice.Based on data mining,basic drugs of Traditional Chinese Medicine were screened and medication rules were analyzed to provide reference for clinical drugs.Methods: 1.CNKI,VIP,Wanfang Database,CBMdisc,Pub Med,Embase and Cochrane Elibrary databases were searched,and RCT trials of Traditional Chinese Medicine in the treatment of patients with damp-heat chronic hepatitis B jaundice from January 2002 to December 2022 were searched.After data extraction,literature quality was assessed by the "bias risk assessment" criteria developed by the Cochrane Collaboration network.Meta-analysis was performed using Review Manager 5.4 software to compare the total effective rate,TBIL,AST,and AST outcome indicators respectively.2.The Traditional Chinese Medicine prescriptions involved in the literature included in the meta-analysis were recorded into the "The Ancient and Modern Medical Records Cloud Platform" to study the medication rules of traditional Chinese medicine in the treatment of patients with damp-heat chronic hepatitis B with jaundice.Results: 1.Meta analysis: A total of 15 RCTS were included for Meta analysis,with a total of 1238 cases.The results indicated that the experimental group(Traditional Chinese Medicine combined with conventional medicine treatment)was superior to the control group(conventional medicine treatment alone)in the treatment of jaundice patients with dampness-heat type chronic hepatitis B and the reduction of TBIL,AST,ALT levels.Data mining: the drugs included in the formula with high frequency of treatment were Yinchen,Poria,Gardenia,Radix Paeoniae Rubra,Licorice,Rhubarb,Salvia,Alisma,Atractylodes,Plantago,Polygonum cuspidatum,Lysimachia,etc.;The four Qi are mainly cold and slightly cold,accompanied by some calming and warm drugs,and the five flavors are mainly bitter,sweet,hot and light.Most drugs mainly belong to liver,spleen and lung channels,accompanied by most stomach,kidney and gallbladder channels.The main drug efficacy is cooling blood detoxification,heat-clearing and detoxifying,choleretic and jaundice-relieving,diuresis and dampness-draining,clearing damp-heat,removing blood stasis and relieving pain,dampness and jaundice-relieving,heat-clearing and dampness-draining,calming heart,invigorating spleen,etc.The occurrence frequency of "poria cocos-Yinchen","Yinchen-gardenia" and "Yinchen-Red Peony" were the highest;The core drug groups were the first group of Atractylodes macrocephala and Alisma plantago-aquatica,and the second group of rhubarb,gardenia,licorice,Salvia miltiorrhiza,paeonia lactiflora,herba artemisiae scopariae and Poria Cocos.Conclusions: 1.Combining conventional medicine with Traditional Chinese Medicine in the treatment of damp-heat type CHB jaundice can significantly improve the therapeutic effect and reduce the level of total bilirubin,ALT and AST in liver function.2.In the treatment of dampness-heat type CHB jaundice,the four Qi are mainly cold and mild cold,and the five flavors are mainly bitter,sweet,hot and light.Most drugs are mainly liver,spleen and lung channels,and the main drug effects are cooling blood detoxification,heat-clearing and detoxifying,choleretic and jaundice-relieving.The occurrence frequency of "poria cocos-Yinchen","Yinchen-gardenia" and "Yinchen-Red Peony" were the highest;The new core formula of cluster analysis was composed of atractylodes atractylodes,alisma alisma,rhubarb,gardenia,licorice,salvia miltiorrhiza,red peony root,wormwood and poria cocos.