| Objectives The purpose of this study is to observe the effects of remote ischemic postconditioning on cognitive impairment and the levels of serum estrogen and inflammatory factors in patients with cerebral infarction,evaluate the effect of remote ischemic postconditioning on improving cognitive impairment in patients with cerebral infarction,and try to find the possible mechanism of this treatment.Methods 1 120 postmenopausal female cerebral infarction patients with non dementia cognitive impairment hospitalized in the Department of Neurology of the Affiliated Hospital of North China University of technology from November 2020 to October 2021 were randomly divided into intervention group and control group.2 The control group was given routine drug treatment,and the intervention group was given remote ischemia adaptation treatment on the basis of routine treatment.All included patients were treated for 14 days.3 Montreal cognitive assessment scale was used to score the cognition of the two groups before treatment,14 days and 30 days of treatment.4 Serum estradiol,interleukin-1 and transforming growth factor were detected by enzyme-linked immunosorbent assay before treatment and 14 days after treatment-β Equal expression level.5 Compare the changes of cognitive score,estrogen,inflammatory factors and other serum indexes between the two groups before and after treatment,and statistically analyze the influence of the improvement of cognitive function after remote ischemia treatment on the expression level of serum estrogen and inflammatory factors before and after treatment.6 Statistical methods: SPSS software is used for data analysis.T-test is used for the comparison of the mean between the two groups,repeated measurement analysis of variance is used for the comparison of the mean between groups at different time points,rank sum test is used for the comparison of the median between groups,and the constituent ratio or rate of counting data is calculated χ~2 Multiple linear regression model was used in multivariate analysis,with P<0.05 as the difference,which was statistically significant.Results 1 There was no significant difference in Montreal cognitive score between the two groups before treatment(P>0.05).The Montreal cognitive score of the two groups increased after 14 and 90 days of treatment,but the change range of the intervention group was more significant(P<0.05).There were significant differences in inter group,time and interaction effects(P<0.05).2 There was no significant difference in the levels of serum estrogen and inflammatory factors between the two groups before treatment(P> 0.05).On the 14 th day of treatment,the levels of serum estrogen in the two groups were higher than those before treatment,and the increase range in the intervention group was more significant(P<0.05);The level of interleukin-1 in inflammatory factors was lower than that before treatment,and the decrease was more obvious in the experimental group(P<0.05);Transforming growth factor β Compared with that before treatment,it increased,and the decrease range of the intervention group was more obvious,the difference was statistically significant(P<0.05).3 Multivariate analysis showed that after excluding other influencing factors,whether to give limb remote ischemia treatment still had a significant impact on the cognitive function of patients,and also had an impact on the changes of serum estrogen level and in vivo inflammatory level(P<0.05);In addition,after treatment,the increase of estrogen level and the change of inflammation level can also affect the recovery of cognitive function,and the difference is statistically significant(P<0.05).Conclusions 1 The adaptive therapy after remote ischemia can improve the cognitive function of postmenopausal women with mild vascular cognitive impairment without obvious adverse reactions.2 Adaptive therapy after remote ischemia can affect the expression of estrogen and inflammatory factors,up regulate the level of estradiol and up regulate transforming growth factor in patients with cerebral infarction-β Level,down regulate the level of interleukin-1,so as to reduce the inflammatory level of patients.The cognitive function of postmenopausal women with cerebral infarction can be improved by remote ischemic postconditioning therapy.Its mechanism may be related to the up regulation of estradiol level and the inhibition of inflammatory response.Figure 1;Table 12;Reference 138... |
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