Research On The Relationship Between Coronary Artery Stenosis, High-sensitivity C-reactive Protein (hs-CRP) And Platelet To Lymphocyte Ratio (PLR)

ObjectiveTo investigate the alterations in the platelet/lymphocyte ratio(PLR)and high-sensitivity C-reactive protein(hs-CRP)in patients with coronary heart disease(CHD)and to examine the relationship between the PLR,high-sensitivity C-reactive protein,and the degree of coronary artery stenosis in order to establish a reference value for the diagnosis of CHD patients and the prognosis of the severity of the disease.MethodsFrom January 2020 to December 2021,cases of suspected coronary heart disease that were admitted and underwent coronary angiography at the Second Affiliated Hospital of Shenyang Medical College were chosen.The non-diseased coronary group(control group,no stenosis),mild coronary stenosis group(stenosis 50%),moderate coronary stenosis group(stenosis 50% and 70%),and severe coronary stenosis group(stenosis 70%)were separated based on the results of the angiography.The random number method was used to choose 100 examples at random from each group.For each instance,information on the gender,age,history of diabetes,hypertension,smoking,family history of coronary heart disease,platelets,lymphocytes,high-sensitivity C-reactive protein,and other factors was gathered.to compare the results between patients who have coronary artery stenosis and those who have not.The presence of independent risk variables for the degree of coronary artery stenosis between PLR and high-sensitivity C-reactive protein was also investigated using logical regression analysis.Moreover,the receiver operating characteristic(ROC)was created to assess their ability to forecast the severity of coronary artery stenosis.Results1.There were significant differences in gender,age,history of hypertension,diabetes,and smoking between the two groups(P=0.000,0.000,0.000,0.000,0.026),however there was no significant difference in family history of coronary heart disease when compared to baseline data(P = 0.68 0.05).The PLR and high-sensitivity C-reactive protein in the group with coronary artery disease were greater than those in the group without coronary artery disease,according to the comparison of clinical data,and the differences were statistically significant(P=0.024 and 0.011).2.Gender,prior history of hypertension,prior cigarette smoking,PLR,and high-sensitivity C-reactive protein were found to be risk variables for the severity of coronary artery stenosis in a single factor logistic regression analysis(P values were all less than 0.05)3.A multivariate logistic regression analysis revealed that the independent risk factors for the severity of coronary artery stenosis were male,history of hypertension,PLR,and high-sensitivity C-reactive protein.4.The ROC curve was drawn to obtain the critical value of PLR in predicting moderate to severe coronary artery stenosis as 119.02,with the sensitivity of 76.5% and specificity of 51%(area under the curve [AUC]: 0.665,95% CI: 0.599–0.732,P<0.001).The cutoff value for high-sensitivity C-reactive protein in predicting moderate to severe coronary artery stenosis was 2.71,with a sensitivity of 45.5% and a specificity of76%(AUC: 0.615,95% CI: 0.55–0.679,P<0.001).The combined predictive probability of PLR and high-sensitivity C-reactive protein for moderate to severe coronary stenosis was 0.66,with sensitivity of 60.5% and specificity of 72%(AUC: 0.71,95%CI:0.649-0.771,P<0.001).Conclusion1.In the group with coronary artery disease,PLR and high-sensitivity C-reactive protein levels are higher than in the group without coronary artery disease.2.For the severity of coronary artery stenosis,male,history of hypertension,PLR,and high-sensitivity C-reactive protein were the independent risk factors.3.High-sensitivity C-reactive protein and PLR can both be utilized as inflammatory indicators to predict coronary artery stenosis,and a combination diagnosis of the two is more useful than a diagnostic made separately.