| Objective The purpose of this study was to investigate the predictive value of factors associated with bone metastasis of prostate cancer.Methods Basic information and relevant clinical data were collected from 160 patients who were diagnosed with prostate cancer by our pathology department from May2021 to December 2022 in the Department of Urology of the Second Affiliated Hospital of Nanchang University,who underwent trans-perineal prostate puncture biopsy.The age,serum calcium,alkaline phosphatase(ALP),Gleason score,prostate-specific antigen,free prostate-specific antigen,prostate-specific antigen density and free prostate-specific antigen to total prostate-specific antigen ratio as well as the importance and predictable value of subject operating characteristic(ROC)curves for the diagnosis of prostate cancer bone metastases were compared between the two groups based on reports of sex radionuclide whole-body bone imaging at the time of admission.Results In this study,160 patients were included,divided into 25 in the bone metastasis group and 135 in the no-bone metastasis group.There was no statistically significant difference between the age,blood calcium,and free prostate-specific antigen to total prostate-specific antigen ratio in the bone metastasis group and the no-bone metastasis group(P>0.05);the alkaline phosphatase,free prostate-specific antigen,and prostate-specific antigen density of patients in the bone metastasis group were(188.44±264.11)U/L,(27.98±18.32)ng/m L,and(3.22±2.45)ng/m L/? than(78.06±19.54)U/L,(7.39±10.77),and(1.18±1.45)ng/m L/? in the group without bone metastases ?.The differences between free prostate-specific antigen,alkaline phosphatase,and prostate-specific antigen density in the group with bone metastases and the group without bone metastases were statistically significant(P<0.05);achi-square test was performed to know that the differences between Gleason score and total prostate-specific antigen in the group with and without bone metastases were statistically significant(P<0.05).Regression analysis was applied to the indicators that were statistically significant in the t-test and chi-square test for univariate analysis,and the results were as follows: alkaline phosphatase(ALP),free prostate-specific antigen,and Gleason score were statistically significant differences in the regression analysis(P<0.05),indicating that these three indicators are risk factors for the development of bone metastasis in prostate cancer.The area under the curve was calculated from the characteristic working curves of the subjects,and it was learned that the area under the curve for the three was 0.730,0.847 and 0.775,respectively,and all three yielded an area under the curve greater than 0.7,indicating that ALP,FPSA and Gleason score are of reference value in the diagnosis of bone metastasis in prostate cancer.the minimum reference for ALP,FPSA and Gleason score standards were 107.55 U/L,15.55 ng/ml and 7.5 points,respectively,and the sensitivities for diagnosing bone metastases from prostate cancer were 52.0%,72.0%and 88.0%,respectively,corresponding to specificities of 99.2%,90.4% and 60.0%,respectively.Conclusion Alkaline phosphatase(ALP),free prostate-specific antigen(FPSA)and Gleason score are useful in the evaluation of prostate cancer with bone metastases,but we should pay more attention to alkaline phosphatase >107.55 U/L,free prostate-specific antigen >15.55 ng/m L and Gleason score ≥8 for the high incidence of bone metastases,which should be given priority attention. |
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