| Purpose:There is a clinical heterogeneity between early-onset Parkinson’s disease(EOPD)and late-onset Parkinson’s disease(LOPD),but the mechanism is not clear,and this study attempts to explore the Regional Homogeneity(Re Ho)of brain regions in the resting state of patients with early and late-onset Parkinson’s disease.Methods:According to the inclusion and exclusion criteria,50 cases of Parkinson’s Disease(PD)group and 50 cases of Health Control(HC)group were included in this study.The PD group was divided into early-onset PD group(EOPD,age ≤ 50 years,N =25)and late-onset Parkinson’s disease(LOPD,age> 50 years,n=25);The Healthy Control group was divided into Younger Healthy Control group(YC,age≤50years,n=25)and Older Healthy Control group(OC,age ≤ 50 years,n=25).Participants were assessed on the United Parkinson Disease Rating Scale(UPDRS),mini-mental State Examination(MMSE),and Hamilton Depression Scale(HDS)on the clinical psychological scale,and were evaluated on resting-state functional magnetic resonance imaging(rs-f MRI),and then using DPABI software to preprocess the data,calculate the Re Ho of each brain region and compare and analyze the differences in Re Ho of each group.Results:In the early-onset Parkinson’s disease group,Re Ho in the right posterior central gyrus was lower than that in the young control group(p< 0.05).Compared with the elderly control group,Re Ho values of right cerebellum,bilateral Sub-lobar and right insula in patients with late-onset Parkinson’s disease were increased(p < 0.05).The Re Ho values of right dorsolateral superior frontal gyrus,left insula,right posterior central gyrus,left parietal gyrus,left anterior central gyrus,right auxiliary motor area,right parietal lobule and right superior temporal gyrus decreased(p<0.05).Conclusions:Some brain regions of early-onset and late-onset Parkinson’s disease have Re Ho abnormalities in resting state.These findings provide a new imaging basis for understanding the clinical heterogeneity of EOPD and LOPD. |
