| Objective:To observe the clinical effect of modified Jingfangfang combined with light-emitting diodes-low-level light therapy(LED-LLLT)on wind-heat type facial corticosteroid addictive dermatitis(FCAD)and the effect on the changes in serum IFN-γ,IL-4 and IL-6 levels.The effectiveness and safety of the treatment are evaluated by evaluating the symptom points and detection indicators before and after treatment,so as to provide new ideas for the clinical treatment of this disease.Methods:The 91 patients with FCAD(wind-heat type)who were finally enrolled in the study were divided into combined group,light group and Chinese medicine(TCM)group by random grouping,and the enrollment ratio was 32:29:30.All three groups were given ebastine.The combined group was given Jingfangfang and infrared-yellow light irradiation,the light group was given infrared-yellow light irradiation,and the TCM group was given Jingfangfang,and the treatment course was 8 weeks.The changes in various symptom scores,FCAD severity index,quality of life index and serum IFN-γ,IL-4 and IL-6 levels and their correlations with FCAD severity were evaluated in the three groups before,4 weeks after treatment and 8 weeks after treatment,and the clinical efficacy of the three groups was evaluated 4 weeks and 8 weeks after treatment according to the changes in symptom scores.Liver and kidney function will be tested before and after the study and adverse reactions during the study will be recorded.SPSS 26.0 was used to compare differences and correlations between and within groups.Results:1.Data: Among the enrolled,there were 14 males and 77 females,with a ratio of1:5.5.The age of onset was mainly between 30~50 years old,and the shortest course of disease was 2 months and the longest was 57 months.In terms of medication,the number of people using dexamethasone was the largest,accounting for 24.17%, followed by triamcinolone acetonide accounting for 19.78%,hydrocortisone butyrate16.48%,clobetasol propionate 10.98%,mometasone furoate 8.79%,desonide 5.49%,drug ingredients unknown or after the use of cosmetics and skin care products accounted for 14.28%.2.Clinical efficacy: 4 weeks after treatment,the number of cured,effective,effective and ineffective cases in the three groups was: 5,8,12 and 7 in the combined group,with a total effective rate(TER)of 78.12%;There were 2,6,11 and 10 people in the light group,with a TER of 65.51%;In the TCM group,1,6,10 and 13 people,the TER was 56.67%,and there was no difference between the three groups(P>0.05).8weeks after treatment,the number of cured,effective,effective and ineffective cases in the three groups was: 13,11,5 and 3 in the combined group,with a TER of 90.62%;There were 5,10,7 and 7 people in the light group,and the TER was 75.86%;There were 3,8,10 and 9 people in the TCM group,with a TER of 70%.There was a difference between the three groups(P<0.05),and further analysis and comparison,there was a difference between the combined group and the light group and the TCM group(P<0.05),there was no difference between the light group and the TCM group(P>0.05),and the clinical efficacy of the combined group was better than that of the other two groups.3.Symptom points: 4 weeks and 8 weeks after treatment,there was no difference in the degree of tingling,telangiectasia and tightness score change between the three groups(P>0.05),and the efficacy of the combined group and the light group was similar(P>0.05)in improving erythema symptoms,but both were better than those in the TCM group(P<0.05).The combined group was better than the other two groups(P<0.05)in relieving itching symptoms,and there was no difference between the light group and the TCM group(P>0.05).There was no difference in burning and affected area changes in the group four weeks after treatment(P>0.05),and the change was more significant in the combined group 8 weeks after treatment than the other two groups(P<0.05),and there was no difference between the light group and the TCM group(P>0.05).At the 4th week after treatment,there was no difference in the FCAD everity index between the three groups(P>0.05),and the FCAD severity index in the combined group was lower than that of the other two groups(P<0.05)at 8th week after treatment,and there was no difference between the other two groups(P>0.05).4.DLQI: There was no difference in DLQI between the three groups at 4 weeks after treatment(P>0.05).The DLQI in the combined group was lower than that in the other two groups(P<0.05)at 8 weeks after treatment,and there was no difference between the other two groups(P>0.05).5.Cytokines: IFN-γ levels were elevated in all three groups after treatment,higher in the combined group than in the other two groups(P<0.05),and no difference in the other two groups(P>0.05).The IL-4 levels in the three groups were reduced,and there was no difference between the combined group and the TCM group(P>0.05),but both groups were lower than those in the light group(P<0.05),and the IL-6 levels in the three groups decreased after treatment,and there was no difference between the three groups(P>0.05).6.Correlation: The FCAD severity index of the three groups was negatively correlated with IFN-γ level and positively correlated with IL-4 level,and the FCAD severity index of the combined group and the light group was positively correlated with IL-6 level.Conclusion: Jingfangfang combined with LED-LLLT infrared-yellow light can improve the symptoms and reduce inflammation in patients with wind-heat type facial corticosteroid addictive dermatitis,which is more advantageous than monotherapy.The mechanism may be up-regulated IFN-γ level,down-regulated IL-4 and IL-6level,and corrected Th1/Th2 balance. |
PDF Full Text Request