Clinical Study On Jianpi Qushi Prescription For Treating Prediabetes (Spleen Deficiency And Dampness Accumulation Syndrome)

Objective Through the clinical observation of Jianpi Qushi prescription in the treatment of prediabetes(Spleen deficiency and dampness accumulation syndrome),the efficacy and safety of Jianpi Qushi prescription were discussed,providing ideas for the diagnosis and treatment of prediabetes with traditional Chinese medicine.MethodsA total of 52 patients with prediabetes who met the inclusion criteria in the inpatient or outpatient department of Endocrinology,The First Affiliated Hospital of Anhui University of CM from September 2020 to December 2022 were randomly divided into two groups.The control group was given routine basic treatment,and the treatment group was given Jianpi Qushi prescription on the basis of the control group,26 patients in each group.After 12 weeks,tumor necrosis faction-α(TNF-α),superoxide dismutase(SOD),blood glucose(fasting blood glucose,2 hours post-meal blood glucose),glycosylated hemoglobin,fasting insulin,blood lipid(serum cholesterol,triglyceride,high density lipoprotein cholesterol,low density lipoprotein cholesterol),waist circumference,hip circumference,body mass index and other indexes of the two groups were observed.As well as TCM syndrome scores and symptom changes,SPSS 23.0software was used to analyze the above data.Results1.Comparison of patients’ general conditions:The age,sex,weight,waist circumference,hip circumference,body mass index and therapeutic indexes(blood glucose metabolism indexes,blood lipid metabolism indexes,liver and kidney function)of 52 patients with pre-diabetes included in the treatment group(26 patients in the treatment group and 26 patients in the control group)were analyzed before treatment.The basic data of the two groups had no significant effect on the study indexes(P > 0.05),and were comparable.2.Comparison of general indicators after treatment: the weight,body mass index,waist circumference and hip circumference of the two groups all decreased before and after treatment.After statistical analysis,the intra-group comparison(P < 0.05)showed that the weight and body weight index of the treatment group were significantly different(P< 0.01);Comparison of curative effect between groups showed differences(P < 0.05).3.Comparison of therapeutic indexes after treatment:(1)Glucose metabolism indexes: After periodic treatment,glucose metabolism indexes of the two groups were decreased compared with before treatment(P < 0.05),and FPG and 2h PG of the treatment group were significantly different(P < 0.01);There was a difference in curative effect between the two groups(P < 0.05).(2)Lipid metabolism indexes: After periodic treatment,lipid metabolism indexes of the two groups were decreased compared with those before treatment(P < 0.05),and TC and TG of the treatment group were significantly different(P < 0.01);There was a difference in curative effect between the two groups(P < 0.05).(3)Inflammatory factor index: After periodic treatment,TNF-α in 2 groups was decreased compared with before treatment(P < 0.05),and TNF-α in treatment group was significantly different(P < 0.01);There was a difference in curative effect between the two groups(P < 0.05).(4)Oxidative stress factors: After periodic treatment,SOD in 2 groups was increased compared with before treatment(P < 0.05),and SOD in treatment group was significantly different(P < 0.01);There was a difference in curative effect between the two groups(P < 0.05).4.Comparison of safety indexes after treatment: After periodic treatment,ALT,AST and Scr in 2 groups were decreased compared with before treatment(P > 0.05);There was no difference in curative effect between the two groups(P > 0.05).5.Comparison of TCM syndrome score,efficacy of TCM syndrome and incidence of adverse reactions after treatment:After periodic treatment,TCM syndrome scores of 2 groups were decreased(P < 0.05);In addition,the mean of the treatment group decreased more than that of the control group,and there was a difference in the efficacy between the groups(P < 0.05).After periodic treatment,the total effective rate of TCM syndromes in the treatment group and the control group was 80.77% and 65.38%,respectively,and the treatment group was better than the control group(P < 0.01).After periodic treatment,no obvious symptoms such as discomfort and no adverse reactions occurred in both groups.Conclusions1.Jianpi Qushi Prescription can reduce the weight,waist circumference,hip circumference,BMI and other indicators of pre-diabetic patients;It can significantly reduce FPG,2h PG,TC,TG,TNF-α and other glucolipid metabolic indexes and inflammatory factor indexes,and increase oxidative stress factor index SOD;2.Jianpi Qushi Prescription can reduce the TCM syndrome score of pre-diabetic patients.The total effective rate of the treatment group was 80.77%,and that of the control group was 65.38%.3.No adverse reactions occurred before and after the intervention of Jianpi Qushi prescription,with high safety.4.Jianpi Qushi Prescription can improve the clinical symptoms of pre-diabetic patients,which is safe and reliable and has clinical application value.