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Clinical Observation Of Jianpi Huatan Recipe In The Treatment Of Obese PCOS-IR Patients With Spleen Deficiency And Phlegm-dampness Syndrome

Posted on:2022-09-14Degree:MasterType:Thesis
Country:ChinaCandidate:J H LiFull Text:PDF
GTID:2514306317488364Subject:TCM gynecology
Abstract/Summary:PDF Full Text Request
Objective: In this study,the clinical efficacy of Jianpi Huatan Decoction combined with metformin hydrochloride sustained-release tablets in the treatment of obese polycystic ovary syndrome with insulin resistance(PCOS-IR)patients with spleen deficiency and phlegm-dampness syndrome was observed.The control group was Western medicine conventional treatment metformin hydrochloride sustained-release tablets.Compare the clinical efficacy of the prescription before and after treatment,the changes in TCM syndrome scores and related indicators,in order to clarify the clinical treatment effect of the empirical prescription on the disease and clarify the relative advantages of the prescription,for future clinical treatment and basic research Provide new treatment plans and research ideas.Methods: This study selected 60 outpatient cases of obese PCOS-IR patients who were clinically diagnosed as obese patients with spleen deficiency and phlegm-dampness during the period from June 2020 to December 2020 in the gynecological clinic of the First Affiliated Hospital of Hunan University of Traditional Chinese Medicine.According to the principle of random grouping,divided into treatment group(Jianpi Huatan prescription + metformin hydrochloride sustained-release tablets)and control group(metformin hydrochloride sustained-release tablets)30 cases each.Observe and record the clinical efficacy,TCM syndrome score,body mass index(BMI),weight,anti-Müllerian hormone(AMH),sex hormone binding globulin(SHBG),leptin(LEP),single The changes of nuclear cell chemoattractant protein-1(MCP-1)and vitamin D levels were analyzed statistically.Results:(1)Before treatment,there was no statistically significant difference between the two groups of patients in terms of age,disease course,height,weight,BMI,and the total score of TCM syndromes(P>0.05),and they were comparable.(2)The total effective rate of TCM syndromes in the treatment group was higher than that in the control group,and the difference was statistically significant(P <0.05).(3)After treatment,the scores of TCM syndromes in the two groups were lower than before treatment,and the treatment group was lower than the control group,the difference was statistically significant(P <0.05).(4)After treatment,the weight,BMI,AMH,LEP and MCP-1 of the two groups were lower than before treatment,the difference was statistically significant(P <0.05),and SHBG was higher than before treatment,the difference was statistically significant(P < 0.05),the treatment group is better than the control group.Vitamin D levels after treatment were higher than before treatment,and the effects of the two groups were similar.(5)No adverse reactions occurred in the treatment group during the treatment period,and 1 gastrointestinal adverse reaction occurred in the control group during the treatment period.Conclusion:Both groups have curative effects in the treatment of obese PCOS-IR patients with spleen deficiency and phlegm-dampness syndrome,and the combined medication group has better curative effect;and the combined medication group is better than single use in improving TCM syndromes Western medicine group.Jianpi Huatan prescription combined with metformin hydrochloride sustained-release tablets can effectively reduce BMI,body weight,AMH,leptin,MCP-1 levels,and increase SHBG and vitamin D levels.During the treatment period,the combined medication group had no adverse events,indicating that the combined medication group is safe and effective in treating obese PCOS-IR patients with spleen deficiency and phlegm-dampness syndrome,and has clinical research value.
Keywords/Search Tags:Polycystic ovary syndrome, Insulin resistance, Jianpi Huatan prescription, Spleen deficiency and phlegm-dampness syndrome, Metformin hydrochloride sustained-release tablets
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