Clinical Study Of Tongdu Tiaoshen Acupuncture Combined With Transcranial Rirect Current Stimulation In The Treatment Of Post-stroke Depression

Objective:To observe the therapeutic efficacy of Tongdu Tiaoshen acupuncture plus Transcranial Direct Current Stimulation(t DCS)for Post-Stroke Depression(PSD),and to evaluate the clinical value of Tongdu Tiaoshen acupuncture combined with t DCS in the treatment of PSD,so as to explore new ideas and methods for clinical treatment of PSD.Methods:The study included 64 eligible patients with PSD who were stochastic into two groups.After exclusion and stratification,finally,60 patients were finally included-30 in the pilo group and 30 in the pilot group.Both groups of patients were given conventional treatment(basic drugs and cognitive behavioral therapy).The control group was treated with t DCS on the basis of conventional treatment,once a day,20 minutes each time,5 times a week for 4 weeks.Based on the control group,the pilot group was treated with Tongdu Tiaoshen acupuncture for 30 minutes once a day,5 times per week for 4 weeks.Before and after therapy,Hamilton Depression Scale(HAMD-24),Montgomery-Asberg Depression Rating Scale(MADRS),National Institute of Health Stroke Scale(NIHSS)and plasma 5-hydroxytryptamine(5-HT)and norepinephrine(NE)were used as evaluation indexes to evaluate the efficacy.The Information were solved by SPSS26.0,the P<0.05 represent the meaning has distinctly differences.Results:(1)Comparison of the two groups,age,sex,type of stroke and course of disease were not noticeable different(P>0.05).(2)In terms of depression scale score:The HAMD and MADRS scores did not differ distinctly before therapy(P>0.05).After treatment,the HAMD and MADRS scores of the two groups were lower than those before treatment and there was a significant difference(P<0.05),but the pilot group decreased more than the control group,the disparity was statistically distinctly(P<0.05),showed that the pilot group was able to reduce PSD symptoms better than the control group.(3)In terms of neurological function recovery: Prior to therapy,The NIHSS points for both groups have no distinctly disparity(P>0.05).and there was a remarkable reduced in both groups after therapy(P<0.05),but the disparity between the two groups was not remarkable(P>0.05).This indicates that the efficacy of the pilot and control groups is comparable in restoring neurological function in patients with PSD.(4)In terms of monoamine neurotransmitter content: The level of 5-HT and NE for both groups were not significantly different before treatment(P>0.05).But the level of5-HT、NE in both groups increased after treatment,and the difference was statistically significant(P<0.05).Relative to the control group,the control group had a greater decrease(P<0.05),This result indicates better efficacy in the pilot group.(5)Comparison of clinical efficacy: After treatment,the total effective rate of the experimental group was 90.0 %,and that of the control group was 76.7 %,the difference was statistically significant(P<0.05).Conclusion:(1)Both groups can improve the depressive symptoms of PSD patients,increase the content of serum 5-HT and NE,and promote the recovery of neurological function.(2)The experimental group was superior to the control group in reducing HAMD and MADRS scores and increasing serum 5-HT and NE levels,but there was no significant difference between the two groups in reducing NIHSS scores.(3)The total effective rate of the experimental group was higher than that of the control group,indicating that Tongdu Tiaoshen acupuncture combined with t DCS was better than t DCS alone.