Clinical Study Of Aerobic Exercise Combined With Electroencephalograph Bionic Electrical Stimulation On Cognitive Impairment After Stroke

Objective To observe the effect of aerobic exercise combined with electroencephalograph bionic electrical stimulation on patients with post-stroke cognitive impairment(PSCI),and the effects on serum brain-derived neurotrophic factor(BDNF)and matrix metalloproteinase9(MMP-9)in patients with PSCI,and explore its possible mechanism.MethodsFifty-two persons with PSCI were randomly divided into a control group of 22 and a experimental group of 25.In addition to 5 cases discharged halfway,47 cases completed the study,namely 22 cases in the control group and 25 cases in the experimental group.In addition to routine rehabilitation treatment,the control group was given electroencephalograph bionic electrical stimulation once a day,5 days per week for 4weeks,while the experimental group performed 30 min of aerobic exercise using a cycle ergometer 5 times a week for 4weeks.Before and after the intervention,cognitive functioning was measured using the Mini-mental State Examination(MMSE)and the Montreal cognitive assessment(Mo CA).Meanwhile,4～5ml of venous blood was collected before eating in the morning to detect the content of brain-derived neurotrophic factor and matrix metalloproteinases 9 in blood serum,and the statistical correlation between the changes of BDNF and MMP-9 in serum and the added value of MMSE score in patients after treatment was analyzed.ResultsThe average MMSE score of both groups had improved significantly after the treatment,with significantly better improved in the experimental group.After the treatment,the average Mo CA score of the experimental group had improved significantly while that of the control group had not.The average serum BDNF increased after the treatment in the both groups and the increase was weakly positively correlated with the increase in MMSE scores.The average MMP-9 content of the both groups decreased after the treatment and the decrease was positively correlated to the increase in the MMSE scores but again weakly.ConclusionAerobic exercise combined with electroencephalograph bionic electrical stimulation can better improve the cognitive function of patients with cognitive impairment after stroke.The increase of serum BDNF and the decrease of MMP-9 were weakly positively correlated with the improvement of cognitive function.