| Objective:Using data mining technology,to retrospectively study Professor Li Ji’s treatment of chronic gastritis outpatients’ medical records,and preliminarily summarize and analyze Professor Li Ji’s medication rules and related academic thoughts in the treatment of chronic gastritis,so as to provide reference for Chinese Medicine clinical practice.Methods:Collected the medical records of chronic gastritis outpatients diagnosed and treated by Professor Li Ji from January 2016 to June 2022,and standardized the first treatment information and prescriptions of 264 medical records meeting the research standards,then established a database.Used WPS Excel 2019 and Traditional Chinese Medicine inheritance computing platform V3.0 software to perform frequency analysis,association rule analysis and cluster analysis on the database data,and explored the potential medication rules of Professor Li Ji in the treatment of chronic gastritis,and discussed and analyzed its related academic thoughts on treatment.Results:1.Among the 264 cases included in this study,90 are male patients and 174 are female patients,with a male-to-female ratio of about 1:2,and the age of onset was mainly concentrated between 50 and 69 years.2.Symptoms that occurred frequently during medical visits mainly included xerostomia,stomach bloating pain,acid regurgitation,bitter taste,etc.The most frequent symptoms were xerostomia,and stomach bloating pain,accounting for 53.79%and 42.42%respectively.The more frequent syndrome types were mainly hepatogastric stagnation syndrome,hepatogastric muggy syndrome,stomach Yin deficiency syndrome,deficiency-cold in spleen and stomach syndrome,spleen-stomach dampheat syndrome,Qi deficiency of the spleen and stomach syndrome,The hepatogastric stagnation syndromewas the most,accounting for 30.30%.3.Among the 264 prescriptions included in this study,111 Chinese medicines were shared with a total frequency of 2930 times.Among them,a total of 46 medicines were used with a frequency of≥10 times,with a total frequency of 2708 times,accounting for 92.42%of the total frequency.Among them,the most frequently used therapeutic medicines included Roasted licorice,Atractylodes macrocephala,Tangerine peel,Amomum villosum,Rhizoma pinellinae praeparata,Poria cocos,White peony,Radix bupleuri,Coptis chinensis and Cortex magnoliae officinalis.4.The efficacy categories of the therapeutic medicines were mainly tonic medicines,qi-regulating drugs,damp-clearing medicine,and heat-clearing drugs.The main ones were tonic medicines,accounting for 28.94%.Among the tonic medicines,Qi-tonifying medicines were the most,accounting for 71.7%of tonic medicines.5.The four natures of the therapeutic medicines were mainly warmness,coldness and neutral in nature;and the five flavors were mainly bitterness,sweetness and pungent in flavor.The channel tropisms of medicines were mainly the spleen,lung,stomach,heart and liver meridian.6.The association rule analysis of therapeutic medicines obtained 44 medicine models and 115 association rules totally.Among them,the top 3 two-medicine combinations with the highest support(excluding licorice)were:Atracty lodes macrocephala,Tangerine peel;Tangerine peel,Amomum villosum;Atractylodes macrocephala,Rhizoma pinellinae praeparata.The top 3 three-medicine combinations with the highest support(excluding licorice)were:Atractylodes macrocephala,Tangerine peel,Amomum villosum;Atractylodes macrocephala,Tangerine peel,Rhizoma pinellinae praeparata;Tangerine peel,Amomum villosum,Rhizoma pinellinae praeparata.The top 3 association rules of two medicines with the highest confidence(excluding licorice)were:Radix bupleuri→White peony;Poria cocos→Atractylodes macrocephala;Amomum villosum→Tangerine peel.The top 3 association rules of three medicines with the highest confidence(excluding licorice)were:Tangerine peel,Poria cocos→Atractylodes macrocephala;Amomum villosum,Rhizoma pinellinae praeparata→Tangerine peel;Tangerine peel,Rhizoma pinellinae praeparata→Atractylodes macrocephala.7.The cluster analysis of therapeutic medicines obtained 6 core medicinecombinations that were more in line with the actual clinical use of the tutor:C1:Roasted licorice,Atractylodes macrocephala,Tangerine peel,Amomum villosum,Poria cocos,Rhizoma pinellinae praeparata,Rhizoma zingiberis,Ginseng;C2:Bamboo shavings,Rhizoma pinellinae praeparata,Atractylodes macrocephala,Roasted licorice,Rhizoma anemarrhenae,Coptis chinensis,Tangerine peel,bamboo leaf;C3:Roasted licorice,White peony,Cyperus rotundus,Tangerine peel,Cuttlebone,Cape jasmine,Rhizoma alismatis,Coptis chinensis;C4:Roasted licorice,Atractylodes macrocephala,Tangerine peel,White peony,Rhizoma pinellinae praeparata,Fructus aurantii,Poria cocos,Radix bupleuri;C5:Roasted licorice,Rehmannia root,Adenophora stricta,Atractylodes macrocephala,Ophiopogon japonicus,ginseng,Rhizoma anemarrhenae,Chinese yam;C6:Roasted licorice,Atractylodes macrocephala,Amomum villosum,Tangerine peel,Poria cocos,Rhizoma pinellinae praeparata,Semen ziziphi spinosae,Ginseng.Conclusion:1.Tonic medicines,qi-regulating drugs,damp-clearing medicine,and heat-clearing drugs were commonly used Chinese medicines categories for the treatment of chronic gastritis by Professor Li Ji.2.Warmness,coldness,neutral,bitterness,sweetness,pungent,spleen meridian,lung meridian,stomach meridian,heart meridian and liver meridian were the natures,flavors and channel tropisms of Chinese medicines commonly used by Professor Li Ji in treating chronic gastritis.3.Roasted licorice,Atractylodes macrocephala,Tangerine peel,Amomum villosum,Rhizoma pinellinae praeparata,Poria cocos,White peony,Radix bupleuri,Coptis chinensis and Cortex magnoliae officinalis were the core common medicines used by Professor Li Ji to treat the chronic gastritis.4.Professor Li Ji takes the treatment of chronic gastritis,based on the transportation of spleen and stomach,attaches attention to the coordination of liver and spleen,and uses the methods of removing dampness,clearing heat and removing blood stasis,in order to achieve the disease and syndrome differentiation. |
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