| Objective:The traditional Chinese medicine prescription of Professor Han Fengjuan for the treatment of perimenopausal AUB-O and the traditional Chinese medicine prescription for the treatment of perimenopausal AUB-O in the literature were collected.The data mining was applied to explore the medication law of the tutor for the treatment of this disease and the general medication law for the treatment of this disease.The characteristic medication of the tutor was summarized in the comparison,and the academic thoughts of the tutor were condensed.Through the analysis of the syndrome types in the literature,the core pathogenesis of the disease was discussed,so as to guide clinical syndrome differentiation and drug use.Methods:Study 1:The prescriptions of Professor Han Fengjuan for the treatment of perimenopausal AUB-O in the gynecological outpatient Department of the First Affiliated Hospital of Heilongjiang University of Chinese Medicine from June 2021 to June 2022 were collected.According to the inclusion and exclusion criteria,a total of 61 patients with perimenopausal AUB-O were sorted out for the first diagnosis.The drug names were standardized and unified,the TCM inheritance assistance platform 2.5,IBM SPSS Modeler 18.0 and IBM Statistics 27.0 were used to analyze the relevant data of the drugs involved,and the medication rule of Professor Han Fengjuan in the treatment of perimenopausal AUB-O was summarized.Study 2:CNKI was used to search the literature related to perimenopausal AUB-O,which was relevant to TCM syndrome classification or clinical trials.Extract relevant data according to inclusion and exclusion criteria and input it into database.TCM inheritance assistance platform 2.5,IBM SPSS Modeler 18.0 and IBM Statistics 27.0 software were used to analyze the data of syndrome types and drugs,and to explore the distribution characteristics of TCM syndrome types,pathogenesis characteristics and prescription rules of AUB-O in perimenopausal period.Results:Study 1:1.61 prescriptions were included,involving 10 5 Chinese herbs.Top 10 Chinese herbs in the list of drug frequency were keel,oyster,dogwood,Paeony,atractylodes,Severus severus,cuttlebone,lotus mortidis,sanguinis sanguinis and astragalus.It involved 16 kinds of Chinese herbal medicine functions,the highest frequency was deficiency supplementing drugs(32.54%),followed by astringent removing drugs(11.14%),surface removing drugs(8.76%),hemostasis drugs(8.01%),liver calming and wind quenching drugs(7.01%),and mind-calming drugs(6.26%).2.Among the four Qi,the warm drugs were the most(42.18%),and the bitter drugs were the most(30.06%).The top 3 channels were liver channel(26.63%),spleen channel(16.68%)and kidney channel(1 6.1 7%).3.Through association rule analysis,18 groups of two-drug combination and 35 groups of three-drug combination were obtained;Three kinds of prescriptions were obtained by cluster analysis.Study 2:1.General information:13 0 clinical trials meeting the requirements were selected,all of which were randomized controlled trials,and no blind method was used in the trials.Treatment courses ranged from 3 weeks to 3 months,and most of them lasted from 1 to 3 months.The total number of participants in the experiment ranged from a minimum of 40 to a maximum of 326,among which the experimental group consisted of a minimum of 20 and a maximum of 163.The patients are between 40 and 60 years old.There were 127 articles divided into 2 groups and 3 articles divided into 3 groups.There were 96 articles involving intervention of western medicine and 37 articles involving intervention of Chinese patent medicine.2.Syndrome characteristics:15 syndrome were sorted out,and the top 3 were kidney deficiency and blood stasis syndrome(23.5 3%),Qi deficiency and blood stasis syndrome(19.61%),and spleen and kidney deficiency syndrome(9.80%).3.Medication law:the top 10 herbs in the ranking of frequency were Astragalus,Madder,white Rhizome,dogwood,Paeoniae paeoniae,Rhizome paeoniae,cooked Rehmannia,Leonurus,Puhuang and raw Rehmannia.The frequency of deficiency supplementing drugs was the highest(45.41%),followed by hemostatic drugs(17.20%),heat-clearing drugs(9.84%),astringent remitting drugs(8.60%),blood circulation and blood stasis removing drugs(6.91%),and surface removing drugs(3.00%).Among the four Qi,the most common was warm medicine(36.74%),and among the five flavors,the most common was sweet(39.7 1%).Hepatic channel(27.98%),renal channel(19.12%)and spleen channel(15.66%)were the top 3.By association rule analysis,6 groups of two-drug combination and 15 groups of three-drug combination were obtained.Five kinds of prescriptions were obtained by cluster analysis.Conclusions:Study 1:1.The high-frequency drugs used by Professor Han Fengjuan in the treatment of perimenopausal AUB-O include:keel,oyster,dogwood,paeonia alba,atractylodis,severus severus,cuttlebone,lotus mortidis,sanguinis sanguinis and astragalus.Professor Han Fengjuan attaches great importance to the use of tonics,astringent drugs,hemostatic drugs and sedative drugs.Tutor treatment of perimenopausal AUB-O drugs mainly warm,bitter,sweet.The meridians involved in drugs are liver,spleen and kidney.2.Professor Han Fengjuan’s academic thoughts on the treatment of perimenopausal AUB-O are as follows:(1)Tonifying liver and kidney,strengthening thoroughfare vessel to stop bleeding;(2)Strengthening the spleen and stomach,elevating yang to stop bleeding;(3)Harmonizing and balancing Yin and Yang.Study 2:1.The common syndromes of AUB-O in perimenopause are syndrome of kidney deficiency and blood stasis,syndrome of qi deficiency and blood stasis,and syndrome of spleen and kidney deficiency.2.The commonly used drugs for the treatment of AUB-O in perimenopausal period are Astragalus,madder,white rhizoma,dogwood,paeoniae alba,severus j aponicus,rehmannia rehmannia,Leonurus,Puhuang,raw Rehmannia Rehmannia,cuttlebone,pixie grass,eqiao,licorice,and Chinese herb.The drugs are mainly used to supplement deficiency,stop bleeding,clear heat,absorb astringent,promote blood circulation and remove blood stasis.In perimenopausal AUB-O treatment,the main drugs were warm and sweet,and the main channels were liver,kidney and spleen.3.The general rules of AUB-O treatment in perimenopausal period are:invigorating qi and invigorating spleen,raising Yang and reinforcing nourishment,tonifying liver and kidney,removing blood stasis and hemostasis,astringent and hemostasis treatment,so as to strengthen the spleen,strengthen the Xiayuan and harmonize qi and blood.4.The drug use patterns of study 1 and study 2 were roughly the same,and there was some overlap in the selection of high-frequency drugs,and the four Qi,five taste and main meridian of drugs were similar.Tutor medication is characterized by the flexible application of the combination of harmonizing Yingwei and Shaoyang to relieve other discomfort in perimenopausal period. |
