Analysis Of Clinical Experience Of Professor Liu Jianqiu In The Treatment Of Upper Airway Cough Syndrome Based On The Traditional Chinese Medicine Inheritance Platform

Objective:The purpose of this study is to collect cases of Professor Liu Jianqiu’s treatment of upper airway cough syndrome,analyze the medication patterns of Professor Liu Jianqiu’s treatment of upper airway cough syndrome using the "Traditional Chinese Medicine Inheritance Assistance Platform(V3.0)" system,and summarize his clinical experience,providing reference basis for the use of traditional Chinese medicine to treat this disease.Methods:We collected cases of upper airway cough syndrome from October 2021 to December 2022,who were treated by Professor Liu Jianqiu of the Respiratory Department of the First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine,sorted out cases that meet the inclusion criteria.The clinical data of patients were entered into the "Traditional Chinese Medicine Inheritance Assistance Platform(V3.0)" system.A "medical record database" has been established to statistically analyze and cluster the gender,age,symptoms,syndromes,and related traditional Chinese medicine and prescription data of patients in the database,thereby discovering hidden new drug groups and forming new prescriptions.Results:1.A total of 100 patients were included in this study,including 33 males and 67 females.The proportion of female patients is higher than that of males.2.In the analysis of all symptoms in 100 patients,cough was the main symptom,cough is characterized by itchy throat,clear throat like cough,irritating cough,cold cough,seasonal cough,postnasal drip like cough,weak cough sound,shortness of breath,and wheezing.Symptoms of the pharynx and nose are mainly present in the concurrent symptoms,there are six physical signs of the pharynx,including posterior wall hyperemia,posterior wall redness and swelling,lymphoid follicular hyperplasia,lateral cord hypertrophy,stuffiness and compression,and unilateral or bilateral breasts.The four types of nasal symptoms include sneezing with a dry nose,stuffy and runny nose,itchy and runny nose,and postnasal drip.The tongue is mainly composed of pale white and reddish tongue,with thin white and white greasy tongue coating,and pulse patterns are mostly floating and thin.3.In this study,the syndrome of cold attacking the lung due to stroke is the most common,followed by the syndrome of wind heat attacking the lung,spleen lung qi deficiency,wind phlegm stagnating the lung,cold dampness obstructing the lung,wind dryness disturbing the lung,lung kidney yin deficiency,lung heat exuberance,phlegm turbidity obstructing the lung,and phlegm and blood stasis syndrome.4.There are a total of 93 traditional Chinese medicines involved in this study,of which the main 10 are Pinellia ternate,Cicada slough,Licorice,Almond,Perilla leaf,Burdock,Poria cocos,Schisandra chinensis,Platycodon grandiflorum,Atractylodes macrocephala,and so on.The four qi of the medicine are mainly warm,cold,and calm,while the five flavors are mainly spicy,bitter,and sweet.The meridians of the medicine are mainly the lung,spleen,and stomach meridians.At the same time,through the "data analysis" module,drugs are analyzed and combined,mining out high-frequency drug pairs,15 groups of corner drugs,and six groups of core drug combinations,including(1)Pinellia ternata,Atractylodes macrocephala,Chicken Neijin,Tangerine peel,and Cicada molting;(2)Poria cocos,licorice,bupleurum,cicada slough,jujube kernel;(3)Pinellia ternate,almond,cicada slough,licorice,perilla leaves;(3)Pinellia ternate,winter flower,aster,cicada slough,licorice;(4)Burdock seeds,licorice,perilla leaves,almonds,pinellia ternata;(5)Poria cocos,bupleurum,jujube kernel,pinellia ternata,Chuanxiong;Three groups of potential drug combinations were extracted from them,including(1)Pinellia ternate,Lonicera japonica,Aster,Cicada slough,Liquorice,Burdock seed,Atractylodes macrocephala,Perilla leaf,and Almond;(2)Pinellia ternate,almond,cicada slough,licorice,perilla leaf,tuckahoe,bupleurum,jujube kernel,Chuanxiong;(3)Pinellia ternate,Atractylodes macrocephala,Chicken Neijin,Tangerine peel,Cicada molt,Poria cocos,Liquorice,Bupleurum,Sour jujube kernel.Conclusions:1.Professor Liu Jianqiu differentiates and treats UACS,and the syndrome of wind and cold attacking the lung is the main syndrome type of this disease,followed by the syndrome of wind and heat attacking the lung,spleen and lung qi deficiency,wind and phlegm stagnating the lung,and cold and dampness blocking the lung.2.The Professor Liu Jianqiu’s high-frequency drugs for the treatment of this disease mainly include pinellia ternate,cicada slough,licorice,almond,perilla leaf,burdock,tuckahoe,schisandra chinensis,platycodon grandiflorum,atractylodes macrocephala and so on.The proportion of the four qi of drugs is high in terms of warmth,cold,and calmness,while the proportion of the five flavors is high in terms of pungent,bitter,and sweet.The proportion of meridians is high in terms of lung,spleen,and stomach meridians.The meridians of the medicine are mainly the lung,spleen,and stomach meridians.Professor Liu advocates the urgency of specimen preparation,adheres to the combination of four diagnostic methods based on the symptoms and signs of the patient,and combines them with modern auxiliary examination results.When prescribing prescriptions,attention should be paid to syndrome differentiation and treatment,and treatment should be based on people.On this basis,both attack and supplement should be applied,both specimens should be taken into account,cold and warm should be used together,hard work should be used together,and lifting and lowering should be appropriate.At the same time,15 groups of high-frequency drug pairs and angle drugs were obtained through clustering analysis and kmeans algorithm;Six core drug combinations and three new prescriptions were simulated by regression.3.Professor Liu Jianqiu believes that the location of UACS is in the lungs,nose,and pharynx,closely related to the spleen and stomach;The main characteristics of the disease are wind and dryness,and there are also many phlegm and dampness.Both cold and heat deficiency and excess can be seen in each other;Nasopharynx dysfunction and lung loss are its basic pathogenesis.In the treatment of UACS,Professor Liu mainly discussed and treated UACS with the main treatment methods of dispersing wind and relieving external symptoms,dispersing the lung and relieving cough,and other different treatment methods such as eliminating phlegm and turbidity,clearing heat and moistening the lung,promoting blood circulation and resolving stasis,and supplementing the spleen and qi.