Detection And Clinical Significance Of Serum SLC7A11 And FGF23 Leves In Patients With Atrial Fibrillation

Objective:To detect atrial fibrillation(AF)and sinus rhythm in patients with serum So lute Carrier Family seven members 11(SLC7A11),serum Fibroblast Growth Factor 23(FGF23)levels,and analysis the correlation between AF and both and its clinical significance.Methods:Selected in December 2019 to July 2020 in the first affiliated hospital of bengbu medical college of cardiovascular internal medicine AF in patients with 118 as the observation group,in accordance with the relevant guidelines divided into paroxysmal AF group 67 cases and Non-paroxysmal AF group 51 cases.96 sinus rhythm of healthy people as control group.Materials.by using enzyme-linked immunoassay(ELISA)detection in the serum SLC7A11,FGF23 levels;Comparison of three groups of patients with clinical data and hematology index,serum SLC7A11 using Pearson correlation analysis,FGF23 levels and echocardiographic centre-left room inside diameter(LAD),left ventricular diastolic diameter(LVD),left ventricular ejection fraction(LVEF)and left ventricular shortening fraction(FS).Multivariate Logsitic regression analysis was used to analyze the persistent related factors of AF in AF patients.Results:1.Compared with control group,serum SLC7A11 in paroxysmal AF group and in non-paroxysmal AF group were decreased(P < 0.01),and non-paroxysmal AF group SLC7A11 lower than that of paroxysmal AF group(P < 0.01),serum FGF23 in paroxysmal AF group and in non-paroxysmal AF group were increased(P < 0.01),and non-paroxysmal AF group FGF23 higher than that of paroxysmal AF group(P < 0.01).2.Pearson correlation analysis showed that LAD and negatively correlated with serum SLC7A11(r = 0.534,P < 0.01),and the positive correlation between serum FGF23(r = 0.532,P < 0.01).3.Multiple Logsitic regression analysis results show that the independent protection SLC7A11 is AF(OR = 0.231,P < 0.01),while FGF23 were independent risk factors(OR = 1.097,P < 0.01).Conclusion:SLC7A11,FGF23 may be associated with the onset and progression of AF.