Effects Of Fasting Blood Glucose On Postoperative Complications And Prognosis In Middle-Aged And Elderly Patients With Colorectal Cancer

Objective: Malignant neoplasms of the colon,rectum and anus(hereafter referred to as "colorectal cancer")have a relatively high incidence and mortality rate among all types of cancers,and their occurrence and development are closely related to the standard of living and diet.Another common and serious chronic disease,diabetes,is also significantly correlated with the living standard and diet of the population.The variable control of fasting glucose in diabetic patients may also have an impact on other aspects of the patient’s life.The purpose of this study was to clarify whether the fasting glucose status of patients is an influential factor in some of the postoperative complications and prognosis of middle-aged and elderly colorectal cancer patients.Methods: A total of 391 patients with colorectal cancer admitted to the anorectal surgery department of the First Affiliated Hospital of China Medical University from April 2020 to February 2021 were selected according to the inclusion and exclusion criteria.The above-mentioned patients were retrospectively analyzed for their general conditions,postoperative complication rates,etc.,so as to compare the differences between the high fasting glucose group(referred to as the "high glucose group")and the normal fasting glucose group(referred to as the "non-hyperglycemic group")in various aspects.The differences between the high fasting glucose group(referred to as "hyperglycemic group")and the normal fasting glucose group(referred to as "non-hyperglycemic group")were compared.Results: 1.There were statistical differences in body weight and BMI between the high fasting glucose group and the normal fasting glucose group(P<0.05),but no clear statistical differences were found between the high fasting glucose group and the normal fasting glucose group in other preoperative laboratory indicators except preoperative fasting glucose,even according to the duration of diabetes.2.There were significant differences in postoperative complications between the high fasting glucose group and the normal fasting glucose group.3.There was no statistically significant difference in postoperative complications and survival even if the patients were grouped according to diabetes duration or sugar control regimen.Conclusion: fasting blood glucose ≥6.1 mmol/L is a risk factor for increased incidence of postoperative complications in patients,but current data do not indicate that fasting blood glucose ≥6.1 mmol/L is a risk factor for increased incidence of total postoperative infection,incidence of incisional infection and incidence of anastomotic fistula in patients;No statistically significant differences were found in this study between patients with high fasting glucose levels of colorectal cancer and patients with normal fasting glucose levels in terms of preoperative levels of various tumour markers,tumour stage and survival.