Prevalence And Associated Risk Factors Of Diabetes Mellitus And Prevalence Of Impaired Fasting Glucose In Uygur And Kazak Populations In Xinjiang

Objective: This study was designed to ethnic differences in the prevalence of type 2 diabetes(T2DM),impaired fasting glucose(IFG) and risk factors of diabetes in Han, Uygur and Kazak ethnic populations from Xinjiang.Methods: A Multistage(region-county-township-village) stratified cluster random sampling method selected adults, living in Yili and Kashi region of Kazakhs and rural Uyghur residents(≥18 years old) in Xinjiang and had their questionnaires, clinical characteristics, anthropometric measurement and standard blood chemistries measured. T2 DM were defined according to WHO 1999 criteria. SPSS software(version 20.0 for Windows; SPSS, Chicago, IL, USA) was used for the statistical analyses. The adjusted odds ratio(ORs) and 95% confidence intervals was calculated for the association of diabetes risk factors in multivariate logistic regression models among Uygur and Kazak.Results: The standardized prevalence of diabetes was 2.4% in Uygur(female: 2.2%, male:2.6%), and5.3% in Kazak(female: 5.9%, male: 4.6%) population, respectively. The standardized prevalence of impaired fasting glucose was 2.8% in Uygur(female: 3.2%, male:2.3%), and 9.3% in Kazak(female: 10.1%,male: 8.1%) population, respectively. The overall standardized prevalence of diabetes and impaired fasting glucose of Kazak was the highest in Uygur ethnic(?2DM=51.770,?2IFG=141.092,P < 0.001). All the prevalence rates were increased with aging. The prevalence rate of diabetes of Kazak men was significantly higher than that of Kazak women(?2=13.162,P< 0.001). Compared by sex, prevalence of IFG of Kazak in obesity and overweight was higher in males(p < 0.05). Compared by Uygur,prevalence of IFG and DM in obesity and overweight was higher in Kazak(p < 0.05). The prevalence of impaired fasting glucose of Kazak men was significantly higher than that of Kazak women(?2=13.162,P<0.001). The results of multivariate logistic-regression analyses showed that diabetes were statistically significantly and positively associated with older age, obesity and hypertension among Uyghur and Kazak adults. Besides,sex males(vs. females), unmarried(vs. married), overweight, triglycerides and smoking(vs. no smoking)were all significantly associated with an increased risk of diabetes in Kazak adults(P<0.05).Conclusions: We found the prevalence of diabetes among Uygur and Kazak was generally lower than the overall national level and lower than among the Han ethnicity, which dominates in China, and a very high prevalence of diabetes in Kazak population but a very low in Uygur in the present study. The results of multivariate logistic-regression analyses showed that diabetes were statistically significantly and positively associated with older age, obesity and hypertension among Uyghur and Kazak adults.