Correlation Between Gamma-glutamyltransferase/Platelet Ratio And Carotid Atherosclerosis In Patients With Type 2 Diabetes Mellitus

Objective: To investigate the correlation between gamma-glutamyltransferase/platelet ratio(GPR)and carotid atherosclerosis(CAS)in patients with type 2 diabetes mellitus(T2DM).Methods: 327 patients with T2 DM were enrolled,and carotid intima-media thickness(CIMT)greater than 0.9mm was considered as CAS.The patients were divided into three groups: There were 154 cases in T2DM(T2DM alone without CAS)group,99 cases in CAS A(T2DM with left/right CAS,normal carotid artery on opposite side)group,and 74 cases in CAS B(T2DM with bilateral CAS)group.General clinical data and laboratory results were collected,and GPR was calculated.SPSS26.0 statistical software was used to analyze the correlation between GPR and CAS.Results: 1.Age,smoking history,history of hypertension,mean values of GPR,platelets(PLT),fasting C-peptide,low-density lipoprotein(LDL)and bilateral CIMT were compared among the three groups,and the differences were statistically significant(P<0.05).2.Spearman rank correlation analysis results showed that GPR in T2 DM patients with body mass index,alanine transaminase,aspartate aminotransferase,?-glutamine transferase,glycosylated hemoglobin,fasting blood sugar,triglyceride,creatinine,double side average CIMT was significantly positively related;There was a significant negative correlation with PLT and high-density lipoprotein.3.Binary Logistic regression analysis showed that old age,smoking history,history of hypertension,GPR and LDL were risk factors for the development of CAS in T2 DM patients.4.Multiple Logistic regression analysis showed that smoking history,hypertension history and GPR were risk factors for unilateral CAS in T2 DM patients.Old age,smoking history,history of hypertension,GPR and LDL are risk factors for bilateral CAS in T2 DM patients,and PLT is protective factor for bilateral CAS in T2 DM patients.5.Receiver operating characteristic(ROC)curve showed that GPR had a certain predictive value for the occurrence of CAS and unilateral and bilateral CAS in T2 DM patients.The area under ROC curve of GPR to predict the risk of CAS in T2 DM patients was 0.839.When GPR=0.132,the sensitivity was 65.3%,specificity was 87.7%,and Yoden index was 0.53.The area under ROC curve to predict the risk of unilateral CAS in T2 DM patients was 0.793.When GPR=0.130,the sensitivity was 70.7%,the specificity was 74.7%,and the Yoden index was 0.454.The area under ROC curve to predict the risk of bilateral CAS in T2 DM patients was 0.811.When GPR=0.152,the sensitivity was 73.0%,specificity was 77.1%,and Yoden index was 0.501.Conclusion: GPR is correlated with T2 DM complicated with CAS,and elevated GPR is a risk factor for CAS in T2 DM patients...